Gisondi Paolo, Bellinato Francesco, Girolomoni Giampiero
Department of Medicine, Section of Dermatology and Venereology, University of Verona, 37126 Verona, Italy.
Vaccines (Basel). 2022 Jul 23;10(8):1171. doi: 10.3390/vaccines10081171.
Clinical and epidemiologic data on pustular psoriasis are scarce. To investigate the phenotypes of pustular psoriasis and the patients' characteristics observed in a real-life retrospective observational study. The number of incident cases of pustular psoriasis registered in the period 2005-2021 was retrieved from the electronic medical records of the University Hospital of Verona. One hundred and forty cases of pustular psoriasis were collected. Ninety-one out of 140 patients (65%) were females, with a median (IQR) age of 57 (43-66) years. According to the ERASPEN classification criteria, 116 patients (83%) had palmoplantar pustulosis (PPP), 13 (9%) generalized pustular psoriasis (GPP), and 11 (8%) acrodermatitis continua of Hallopeau (ACH). Gender distribution and median age were consistent among the three groups. The prevalence of psoriatic arthritis in GPP, ACH, and PPP was 8%, 36%, and 28%, respectively. During the same period, a total of 4718 cases of plaque psoriasis were retrieved, with a 1:34 ratio of pustular over plaque psoriasis. Pustular psoriasis is much rarer than plaque psoriasis, with PPP being the more common subtype.
脓疱型银屑病的临床和流行病学数据稀缺。为了在一项真实世界的回顾性观察研究中调查脓疱型银屑病的表型及观察到的患者特征。从维罗纳大学医院的电子病历中检索了2005年至2021年期间登记的脓疱型银屑病新发病例数。共收集到140例脓疱型银屑病病例。140例患者中有91例（65%）为女性，年龄中位数（四分位间距）为57（43 - 66）岁。根据欧洲银屑病关节炎研究组（ERASPEN）分类标准，116例患者（83%）患有掌跖脓疱病（PPP），13例（9%）患有泛发性脓疱型银屑病（GPP），11例（8%）患有Hallopeau连续性肢端皮炎（ACH）。三组的性别分布和年龄中位数一致。GPP、ACH和PPP中银屑病关节炎的患病率分别为8%、36%和28%。在同一时期，共检索到4718例斑块状银屑病病例，脓疱型与斑块状银屑病的比例为1:34。脓疱型银屑病比斑块状银屑病少见得多，其中PPP是更常见的亚型。
