Department of Meridians and Acupoints, College of Korean Medicine, Kyung Hee University, Seoul 05253, Korea.
Acupuncture & Meridian Science Research Center, Kyung Hee University, Seoul 02447, Korea.
Nutrients. 2022 Jul 25;14(15):3046. doi: 10.3390/nu14153046.
Metabolic syndrome (MetS) is a medical condition characterized by abdominal obesity, insulin resistance, high blood pressure, and hyperlipidemia. An increase in the incidence of MetS provokes an escalation in health care costs and a downturn in quality of life. However, there is currently no cure for MetS, and the absence of immediate treatment for MetS has prompted the development of novel therapies. In accordance with recent studies, the brown seaweed (LJP) has anti-inflammatory and antioxidant properties, and so forth. LJP contains bioactive compounds used as food globally, and it has been used as a medicine in East Asian countries. We conducted a systematic review to examine whether LJP could potentially be a useful therapeutic drug for MetS. The following databases were searched from initiation to September 2021: PubMed, Web of Science, EMBASE, and Cochrane Central Register of Controlled Trials Library. Clinical trials and in vivo studies evaluating the effects of LJP on MetS were included. LJP reduces the oxidative stress-related lipid mechanisms, inflammatory cytokines and macrophage-related chemokines, muscle cell proliferation, and migration. Bioactive-glucosidase inhibitors reduce diabetic complications, a therapeutic target in obesity and type 2 diabetes. In obesity, LJP increases AMP-activated protein kinase and decreases acetyl-CoA carboxylase. Based on our findings, we suggest that LJP could treat MetS, as it has pharmacological effects on MetS.
代谢综合征（MetS）是一种以腹部肥胖、胰岛素抵抗、高血压和血脂异常为特征的医学病症。MetS 发病率的增加会引发医疗保健费用的增加和生活质量的下降。然而，目前还没有治愈 MetS 的方法，而且对 MetS 缺乏即时治疗促使开发了新的疗法。根据最近的研究，褐藻 (LJP) 具有抗炎和抗氧化特性等。LJP 含有生物活性化合物，在全球范围内用作食品，在东亚国家也被用作药物。我们进行了系统评价，以研究 LJP 是否可能成为治疗 MetS 的有用药物。从开始到 2021 年 9 月，我们在以下数据库中进行了搜索：PubMed、Web of Science、EMBASE 和 Cochrane 中央对照试验注册库。纳入了评估 LJP 对 MetS 影响的临床试验和体内研究。LJP 可降低与氧化应激相关的脂质机制、炎症细胞因子和巨噬细胞相关趋化因子、肌肉细胞增殖和迁移。生物活性 -葡萄糖苷酶抑制剂可减少糖尿病并发症，这是肥胖和 2 型糖尿病的治疗靶点。在肥胖中，LJP 增加 AMP 激活的蛋白激酶并减少乙酰辅酶 A 羧化酶。根据我们的研究结果，我们认为 LJP 可以治疗 MetS，因为它对 MetS 具有药理作用。
