健康小于胎龄早产儿的身体成分和“追赶性”脂肪生长与神经发育结局。
Body Composition and "Catch-Up" Fat Growth in Healthy Small for Gestational Age Preterm Infants and Neurodevelopmental Outcomes.
机构信息
Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.
Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
出版信息
Nutrients. 2022 Jul 25;14(15):3051. doi: 10.3390/nu14153051.
To examine the growth and body composition of small for gestational age (SGA) and appropriate for gestational age (AGA) very low birth weight infants (VLBW) and their outpatient neurodevelopmental outcomes. From 2006-2012, VLBW infants ( = 57 of 92) admitted to the Neonatal Intensive Care Unit (NICU) had serial air displacement plethysmography (ADP) scans and were followed as outpatients. Serial developmental testing (CAT/CLAMS, Peabody Gross Motor Scales) and anthropometrics were obtained from = 37 infants (29 AGA and 8 SGA) and analyzed via repeated measures analyses of variances. The percentage of body fat, percentage of lean mass, and weight gain were statistically significant between SGA and AGA groups at the first ADP assessment. There was no difference between the two groups in outpatient neurodevelopmental testing. Weight gain as "catch-up" body fat accrual occurs by 67 weeks of PMA. This catch-up growth is associated with normal SGA preterm neurodevelopment as compared to AGA preterm infants.
目的
探讨小于胎龄儿（SGA）和适于胎龄儿（AGA）极低出生体重儿（VLBW）的生长和身体成分，及其门诊神经发育结局。方法：本研究纳入 2006 年至 2012 年间在新生儿重症监护病房（NICU）住院的 VLBW 婴儿（n=92，其中 57 例），进行了多次空气置换体积描记法（ADP）扫描，并作为门诊患者进行了随访。对 37 例婴儿（29 例 AGA 和 8 例 SGA）进行了连续发育测试（CAT/CLAMS、Peabody 粗大运动量表）和人体测量学检测，并通过方差重复测量分析进行了分析。在第一次 ADP 评估中，SGA 组和 AGA 组之间的体脂百分比、瘦体重百分比和体重增加均有统计学差异。两组间门诊神经发育测试无差异。通过矫正胎龄（PMA）67 周，实现了“追赶”性体脂增加的体重增长。与 AGA 早产儿相比，这种追赶生长与 SGA 早产儿的正常神经发育有关。
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