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J Pediatr. 2020 Jul;222:79-84.e2. doi: 10.1016/j.jpeds.2020.01.058. Epub 2020 Apr 24.
2
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.布洛芬用于治疗早产或低体重（或两者兼具）婴儿的动脉导管未闭。
Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8.
3
To Feed or Not to Feed: A Critical Overview of Enteral Feeding Management and Gastrointestinal Complications in Preterm Neonates with a Patent Ductus Arteriosus.是否喂养：有动脉导管未闭的早产儿肠内喂养管理和胃肠道并发症的批判性综述。
Nutrients. 2019 Dec 27;12(1):83. doi: 10.3390/nu12010083.
4
Milk feed osmolality and adverse events in newborn infants and animals: a systematic review.牛奶渗透压与新生儿和动物不良事件的关系：系统综述。
Arch Dis Child Fetal Neonatal Ed. 2019 May;104(3):F333-F340. doi: 10.1136/archdischild-2018-315946. Epub 2018 Dec 6.
5
Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.安慰剂、吲哚美辛、布洛芬和对乙酰氨基酚与早产儿血流动力学显著的动脉导管未闭闭合的关联：一项系统评价和荟萃分析。
JAMA. 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896.
6
Does ibuprofen treatment in patent ductus arteriosus alter oxygen free radicals in premature infants?布洛芬治疗早产儿动脉导管未闭是否会改变其氧自由基水平？
Cardiol Young. 2017 Apr;27(3):507-511. doi: 10.1017/S1047951116000822. Epub 2016 Jun 20.
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The Effect of Oral High-dose Ibuprofen on Patent Ductus Arteriosus Closure in Preterm Infants.口服高剂量布洛芬对早产儿动脉导管未闭的影响。
Am J Perinatol. 2015 Oct;32(12):1158-63. doi: 10.1055/s-0035-1551671. Epub 2015 May 22.
8
The Association between Patent Ductus Arteriosus and Perinatal Infection in A Group of Low Birth Weight Preterm Infants.一组低出生体重早产儿动脉导管未闭与围产期感染之间的关联
Iran J Pediatr. 2014 Feb;24(1):42-8. Epub 2013 Nov 22.
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Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial.口服对乙酰氨基酚与口服布洛芬治疗早产儿动脉导管未闭的随机对照试验。
J Pediatr. 2014 Mar;164(3):510-4.e1. doi: 10.1016/j.jpeds.2013.11.008. Epub 2013 Dec 18.
10
Effect of oral ibuprofen on patent ductus arteriosus in premature newborns.口服布洛芬对早产儿动脉导管未闭的影响。
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对于患有动脉导管未闭的早产儿，开始肠内给予布洛芬所需的最低喂养量是多少？

What Are the Minimal Feeds Required for Starting Enteral Ibuprofen in Preterm Infants with PDA?

作者信息

Surak Aimann, Hyderi Abbas

机构信息

Northern Alberta Neonatal Program, Philip C. Etches NICU, Royal Alexandra Hospital Site, DTC 5027, 10240 Kingsway NW, Edmonton, AB T5H 3V9, Canada.

出版信息

Pediatr Rep. 2022 Jul 24;14(3):333-337. doi: 10.3390/pediatric14030040.

DOI:10.3390/pediatric14030040
PMID:35894029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9331810/
Abstract

Ibuprofen is commonly used for the treatment of hemodynamically significant patent ductus arteriosus (PDA) in preterm infants. It seems that the oral formulation incurs a higher closure rate and has a better safety profile in preterm infants born > 26 weeks’ gestation. There is no consensus across Canadian centers regarding the minimum volume of enteral feeds required prior to starting ibuprofen for the treatment of patent ductus arteriosus, and the current practice is comfort-based depending on the centre and the local prevalence of neonatal morbidities.

摘要

布洛芬常用于治疗早产儿血流动力学显著的动脉导管未闭（PDA）。对于妊娠>26周出生的早产儿，口服制剂似乎具有更高的闭合率和更好的安全性。加拿大各中心对于开始使用布洛芬治疗动脉导管未闭之前所需的肠内喂养最小量尚无共识，目前的做法是基于舒适度，这取决于中心以及当地新生儿疾病的患病率。