对于患有动脉导管未闭的早产儿，开始肠内给予布洛芬所需的最低喂养量是多少？
What Are the Minimal Feeds Required for Starting Enteral Ibuprofen in Preterm Infants with PDA?
作者信息
Surak Aimann, Hyderi Abbas
机构信息
Northern Alberta Neonatal Program, Philip C. Etches NICU, Royal Alexandra Hospital Site, DTC 5027, 10240 Kingsway NW, Edmonton, AB T5H 3V9, Canada.
出版信息
Pediatr Rep. 2022 Jul 24;14(3):333-337. doi: 10.3390/pediatric14030040.
Abstract
Ibuprofen is commonly used for the treatment of hemodynamically significant patent ductus arteriosus (PDA) in preterm infants. It seems that the oral formulation incurs a higher closure rate and has a better safety profile in preterm infants born > 26 weeks’ gestation. There is no consensus across Canadian centers regarding the minimum volume of enteral feeds required prior to starting ibuprofen for the treatment of patent ductus arteriosus, and the current practice is comfort-based depending on the centre and the local prevalence of neonatal morbidities.
摘要
布洛芬常用于治疗早产儿血流动力学显著的动脉导管未闭（PDA）。对于妊娠>26周出生的早产儿，口服制剂似乎具有更高的闭合率和更好的安全性。加拿大各中心对于开始使用布洛芬治疗动脉导管未闭之前所需的肠内喂养最小量尚无共识，目前的做法是基于舒适度，这取决于中心以及当地新生儿疾病的患病率。
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