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在临床和研究环境中测量和估计胰岛素抵抗。

Measuring and estimating insulin resistance in clinical and research settings.

机构信息

National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa, Italy.

出版信息

Obesity (Silver Spring). 2022 Aug;30(8):1549-1563. doi: 10.1002/oby.23503.

DOI:10.1002/oby.23503
PMID:35894085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9542105/
Abstract

The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue in human participants. The most frequently used methodologies to evaluate insulin resistance are described in detail starting from the gold standard, that is, the euglycemic hyperinsulinemic clamp, to the intravenous glucose tolerance test, surrogate indices based on fasting measurements, or dynamic tests (such as oral glucose or mixed meal tolerance tests). The accuracy, precision, and reproducibility of the tests as well as cutoff values are reported.

摘要

本文讨论了如何在人体参与者中测量肌肉、肝脏和脂肪组织中的胰岛素抵抗。从金标准——即正葡萄糖高胰岛素钳夹试验开始，详细描述了评估胰岛素抵抗最常用的方法学，以及基于空腹测量的替代指标或动态试验（如口服葡萄糖或混合餐耐量试验）。报告了这些试验的准确性、精密度和可重复性以及截止值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/b7b4ae85d217/OBY-30-1549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/fe74c40d0527/OBY-30-1549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/01cb89656f6d/OBY-30-1549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/390edc883b8c/OBY-30-1549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/71c19de70dc2/OBY-30-1549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/b7b4ae85d217/OBY-30-1549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/fe74c40d0527/OBY-30-1549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/01cb89656f6d/OBY-30-1549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/390edc883b8c/OBY-30-1549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/71c19de70dc2/OBY-30-1549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a79/9542105/b7b4ae85d217/OBY-30-1549-g002.jpg

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