Xie Jiang-Biao, Lin Xin-Zhu
Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361001, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Jul 15;24(7):832-837. doi: 10.7499/j.issn.1008-8830.2203134.
Apnea of prematurity (AOP) is one of the common diseases in preterm infants. The main cause of AOP is immature development of the respiratory control center. If AOP is not treated timely and effectively, it will lead to respiratory failure, hypoxic brain injury, and even death in severe cases. Caffeine is the first choice for the treatment of AOP, but its effectiveness varies in preterm infants. With the deepening of AOP research, more and more genetic factors have been confirmed to play important roles in the pathogenesis and treatment of AOP; in particular, the influence of single nucleotide polymorphism on the efficacy of caffeine has become a research hotspot in recent years. This article reviews the gene polymorphisms that affect the efficacy of caffeine, in order to provide a reference for individualized caffeine therapy. Citation.
早产儿呼吸暂停（AOP）是早产儿常见疾病之一。AOP的主要原因是呼吸控制中心发育不成熟。如果AOP得不到及时有效的治疗，将导致呼吸衰竭、缺氧性脑损伤，严重时甚至会死亡。咖啡因是治疗AOP的首选药物，但在早产儿中的疗效存在差异。随着对AOP研究的深入，越来越多的遗传因素被证实在AOP的发病机制和治疗中起重要作用；特别是单核苷酸多态性对咖啡因疗效的影响已成为近年来的研究热点。本文综述影响咖啡因疗效的基因多态性，以期为咖啡因个体化治疗提供参考。引文。
