Andreica V, Dumitraşcu D, Suciu A, Sendrea D, Erdosy S, Drăghici A, Pascu O, Părău N, Galu A
Med Interne. 1987 Jan-Mar;25(1):15-24.
Investigations were carried out on duodeno- and jejunogastric reflux, gastric juice acidity, microbial population and the concentration of nitrites in 199 subjects. In gastric cancer patients or those with gastric ulcer, chronic atrophic gastritis, stomach resection or more seldom with removal of the gallbladder, a significant increase over normal values of the pH, duodenogastric reflux, microbial flora contamination (especially intestinal) and nitrite concentration was found. In smokers the salivary nitrite concentration was greater than in non-smokers and in direct relationship to gastric concentrations. The parallelism of these alterations suggests a causative relation between them and their presence in diseases or conditions of notorious increased incidence in gastric cancer highlights the direction to be followed in the primary prophylaxis of this disease.
对199名受试者进行了十二指肠-空肠胃反流、胃酸度、微生物群落及亚硝酸盐浓度的调查。在胃癌患者或患有胃溃疡、慢性萎缩性胃炎、胃切除术患者中，或较少见的胆囊切除术患者中，发现pH值、十二指肠-胃反流、微生物菌群污染（尤其是肠道菌群）及亚硝酸盐浓度显著高于正常值。吸烟者唾液中亚硝酸盐浓度高于不吸烟者，且与胃内浓度呈正相关。这些改变的平行性表明它们之间存在因果关系，且它们在胃癌发病率显著增加的疾病或状况中的存在突出了该疾病一级预防应遵循的方向。
