Jaskiewicz K, Van Helden P D, Wiid I J, Steenkamp H J, Van Wyk M J
Department of Pathology, University of Cape Town Medical School, Observatory, South Africa.
Anticancer Res. 1990 May-Jun;10(3):833-6.
One hundred and seventy-eight patients at risk for gastric carcinoma had upper gastrointestinal endoscopy. Twenty-seven selected patients with the type B of chronic atrophic gastritis, 32 patients with normal mucosa and 47 non-scoped healthy controls were tested for plasma vitamin C, retinol and tocopherol. The total vitamin C level was also assessed in gastric juice of scoped patients. Micronutrient levels were related to gastric pH, nitrites and gastric mucosal pathology. The study showed a higher level of pH (greater than 4) and high nitrites in gastric juice in patients with chronic atrophic gastritis, gastric malignant and dysplastic lesions. Neither the hypochlorhydria nor gastric nitrites affected the prevalence of C. pylori in gastric mucosa. Low gastric and plasma concentrations of vitamin C observed in patients with chronic atrophic gastritis showed an inverted relationship with pH level, and an inter-relationship of other vitamins with antioxidant properties (vitamins A and E).
178例有胃癌风险的患者接受了上消化道内镜检查。对27例选定的B型慢性萎缩性胃炎患者、32例黏膜正常的患者以及47例未接受内镜检查的健康对照者进行了血浆维生素C、视黄醇和生育酚检测。还对接受内镜检查患者的胃液中的总维生素C水平进行了评估。微量营养素水平与胃pH值、亚硝酸盐及胃黏膜病理学相关。研究显示，慢性萎缩性胃炎、胃恶性病变和发育异常病变患者的胃液pH值较高（大于4）且亚硝酸盐含量高。胃酸过少和胃内亚硝酸盐均不影响胃黏膜中幽门螺杆菌的感染率。慢性萎缩性胃炎患者胃内和血浆维生素C浓度较低，这与pH值水平呈负相关，且与其他具有抗氧化特性的维生素（维生素A和维生素E）存在相互关系。
