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胸腹腔镜切除胸腺小细胞癌后,抗利尿激素分泌不当的副肿瘤综合征完全缓解。

Complete resolution of paraneoplastic syndrome of inappropriate antidiuretic hormone secretion following thymic small-cell carcinoma thoracoscopic resection.

机构信息

Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

出版信息

Interact Cardiovasc Thorac Surg. 2022 Jul 9;35(2). doi: 10.1093/icvts/ivac192.

DOI:10.1093/icvts/ivac192
PMID:35894814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9338702/
Abstract

Thymic neuroendocrine tumours are rare anterior mediastinal neoplasms often associated with paraneoplastic syndromes. A patient presented with intractable hyponatraemia and a DOTATATE-avid mediastinal mass. Following medical optimization, she underwent thoracoscopic thymectomy with en bloc thymic small-cell carcinoma resection. Her symptoms resolved and her sodium levels normalized. In localized disease, curative-intent, minimally invasive thymic neuroendocrine tumour resection is safe and effective following preoperative staging and paraneoplastic syndrome management.

摘要

胸腺神经内分泌肿瘤是一种罕见的前纵隔肿瘤,常与副肿瘤综合征相关。一名患者表现为难治性低钠血症和 DOTATATE 摄取的纵隔肿块。经医学优化后,她接受了胸腔镜胸腺切除术和整块胸腺癌切除术。她的症状得到缓解,血钠水平恢复正常。对于局限性疾病,在术前分期和副肿瘤综合征管理后,采用有治愈意图的微创胸腺神经内分泌肿瘤切除术是安全有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9475/9338702/54b0b676e5a4/ivac192f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9475/9338702/abca72be5609/ivac192f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9475/9338702/54b0b676e5a4/ivac192f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9475/9338702/abca72be5609/ivac192f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9475/9338702/54b0b676e5a4/ivac192f2.jpg

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本文引用的文献

1
A case report of a thymic neuroblastoma associated with syndrome of inappropriate secretion of antidiuretic hormone: Ten-year follow-up results after surgical treatment.一例与抗利尿激素分泌不当综合征相关的胸腺神经母细胞瘤病例报告:手术治疗后的十年随访结果
Int J Surg Case Rep. 2019;58:45-47. doi: 10.1016/j.ijscr.2019.03.056. Epub 2019 Apr 5.
2
Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1: The Mayo Clinic Experience from 1977 to 2013.1型多发性内分泌腺瘤病中的胸腺和支气管类癌肿瘤:梅奥诊所1977年至2013年的经验
Horm Cancer. 2015 Dec;6(5-6):247-53. doi: 10.1007/s12672-015-0228-z. Epub 2015 Jun 13.
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Thymic neuroendocrine carcinoma producing ectopic adrenocorticotropic hormone and Cushing's syndrome.
胸腺癌分泌异位促肾上腺皮质激素并引起库欣综合征。
Ann Thorac Surg. 2013 Oct;96(4):e81-e83. doi: 10.1016/j.athoracsur.2013.04.140.
4
Paraneoplastic syndromes secondary to neuroendocrine tumours.神经内分泌肿瘤相关副肿瘤综合征。
Endocr Relat Cancer. 2010 Jul 28;17(3):R173-93. doi: 10.1677/ERC-10-0024. Print 2010 Sep.
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Primary neuroendocrine tumors of the thymus.胸腺原发性神经内分泌肿瘤
Ann Thorac Surg. 2002 Nov;74(5):1733-40. doi: 10.1016/s0003-4975(02)03547-6.