New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.
Galbreath Equine Center, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH.
Am J Vet Res. 2022 Jul 18;83(9):ajvr.21.08.0133. doi: 10.2460/ajvr.21.08.0133.
To compare the effects of 7.2% hypertonic and 0.9% isotonic saline (sodium chloride) solutions on cardiovascular parameters and plasma arginine vasopressin (AVP) concentrations in healthy, isoflurane-anesthetized horses.
8 healthy horses.
In a prospective, randomized, crossover study, horses were anesthetized with isoflurane twice with a 14-day washout period between anesthetic episodes. While anesthetized, horses received a bolus (4 mL/kg) of 7.2% hypertonic saline solution (HS) or 0.9% isotonic saline solution (IS). Heart rate; systolic, mean, and diastolic arterial blood pressures; and central venous and pulmonary artery pressures were measured every 5 minutes; cardiac output was measured by means of thermodilution every 15 minutes. Systemic vascular resistance (SVR) was calculated. Blood samples were collected before and during anesthesia, and plasma AVP concentrations were determined with a validated ELISA. Data were analyzed with repeated-measures ANOVA and Pearson correlations.
HS caused an increase in systolic (P = .003) and mean (P = .023) arterial blood pressures that lasted for 30 minutes. The SVR was increased (P < .001) for 45 minutes with HS compared with the SVR after IS administration. Mean plasma AVP concentration increased (P = .03) 15 minutes after HS administration, with the increase lasting 90 minutes.
A bolus of HS resulted in a clinically relevant increase in blood pressure in healthy, isoflurane-anesthetized horses. This effect was attributed to volume recruitment and an increase in SVR. Administration of HS offers an option for improving arterial blood pressure in anesthetized horses.
比较 7.2%高渗盐水和 0.9%生理盐水（氯化钠）溶液对健康异氟醚麻醉马心血管参数和血浆精氨酸加压素（AVP）浓度的影响。
8 匹健康马。
在一项前瞻性、随机、交叉研究中，马用异氟醚麻醉两次，两次麻醉之间有 14 天的洗脱期。麻醉时，马接受 4 mL/kg 的 7.2%高渗盐水（HS）或 0.9%等渗盐水（IS）的推注。每 5 分钟测量心率、收缩压、平均动脉压和舒张压；每 15 分钟通过热稀释法测量心输出量。计算全身血管阻力（SVR）。在麻醉前和麻醉期间采集血液样本，并使用经过验证的 ELISA 测定血浆 AVP 浓度。使用重复测量方差分析和 Pearson 相关性进行数据分析。
HS 导致收缩压（P=0.003）和平均动脉压（P=0.023）升高，持续 30 分钟。与 IS 给药后相比，HS 使 SVR 升高（P<.001）45 分钟。HS 给药后 15 分钟，平均血浆 AVP 浓度升高（P=0.03），升高持续 90 分钟。
健康异氟醚麻醉马给予 HS 推注可导致血压显著升高。这种作用归因于容量募集和 SVR 的增加。HS 的给药为改善麻醉马的动脉血压提供了一种选择。
