Muir William W, Kijtawornrat Anusak, Ueyama Yukie, Radecki Steven V, Hamlin Robert L
QTest Laboratories, 6456 Fiesta Dr, Columbus, OH 43235, USA.
J Am Vet Med Assoc. 2011 Sep 1;239(5):630-7. doi: 10.2460/javma.239.5.630.
To determine the hematologic, serum biochemical, rheological, hemodynamic, and renal effects of IV administration of lactated Ringer's solution (LRS) to healthy anesthetized dogs.
4-period, 4-treatment cross-over study.
8 healthy mixed-breed dogs.
Each dog was anesthetized, mechanically ventilated, instrumented, and randomly assigned to receive LRS (0, 10, 20, or 30 mL/kg/h [0, 4.5, 9.1, or 13.6 mL/lb/h]), IV, on 4 occasions separated by at least 7 days. Blood hemoglobin concentration and serum total protein, albumin, lactate, and electrolyte concentrations; PCV; colloid osmotic pressure; arterial and venous pH and blood gases (Po2; Pco2); whole blood and plasma viscosity; arterial and venous blood pressures; cardiac output; results of urinalysis; urine production; glomerular filtration rate; and anesthetic recovery times were monitored. Oxygen delivery, vascular resistance, stroke volume, pulse pressure, and blood and plasma volume were calculated.
Increasing rates of LRS administration resulted in dose-dependent decreases in PCV; blood hemoglobin concentration and serum total protein and albumin concentrations; colloid osmotic pressure; and whole blood viscosity. Plasma viscosity; serum electrolyte concentrations; data from arterial and venous blood gas analysis; glomerular filtration rate; urine production; heart rate; pulse, central venous, and arterial blood pressures; pulmonary vascular resistance; and oxygen delivery did not change. Pulmonary artery pressure, stroke volume, and cardiac output increased, and systemic vascular resistance decreased.
Conventional IV infusion rates of LRS to isoflurane-anesthetized dogs decreased colligative blood components; increased plasma volume, pulmonary artery pressure, and cardiac output; and did not change urine production or oxygen delivery to tissues.
确定对健康麻醉犬静脉输注乳酸林格氏液（LRS）的血液学、血清生化、流变学、血流动力学及肾脏效应。
4期、4种处理的交叉研究。
8只健康杂种犬。
每只犬麻醉后进行机械通气、仪器监测，并随机分配接受LRS（0、10、20或30 mL/kg/h [0、4.5、9.1或13.6 mL/lb/h]）静脉输注，分4次进行，每次间隔至少7天。监测血红蛋白浓度、血清总蛋白、白蛋白、乳酸及电解质浓度；红细胞压积；胶体渗透压；动脉和静脉pH值及血气（Po2；Pco2）；全血和血浆粘度；动脉和静脉血压；心输出量；尿液分析结果；尿量；肾小球滤过率；以及麻醉恢复时间。计算氧输送、血管阻力、每搏输出量、脉压以及血容量和血浆容量。
LRS输注速率增加导致红细胞压积、血红蛋白浓度、血清总蛋白和白蛋白浓度、胶体渗透压及全血粘度呈剂量依赖性降低。血浆粘度、血清电解质浓度、动脉和静脉血气分析数据、肾小球滤过率、尿量、心率、脉搏、中心静脉压和动脉血压、肺血管阻力及氧输送未发生变化。肺动脉压、每搏输出量和心输出量增加，全身血管阻力降低。
以常规静脉输注速率对异氟烷麻醉犬输注LRS可降低血液胶体成分；增加血浆容量、肺动脉压和心输出量；且不改变尿量或组织氧输送。
