转诊机构收治的急性腹泻马的治疗方法：一项多中心回顾性研究。

Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study.

机构信息

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, United States of America.

出版信息

PLoS One. 2024 Nov 20;19(11):e0313783. doi: 10.1371/journal.pone.0313783. eCollection 2024.

DOI:10.1371/journal.pone.0313783

PMID:39565809

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11578493/

Abstract

BACKGROUND

This study aimed to describe and compare therapeutic approaches for horses with acute diarrhea in different geographic regions worldwide.

METHODS

Clinical information was retrospectively collected from diarrheic horses presented to participating institutions between 2016 and 2020, including fluid therapy on admission, antimicrobial drugs, probiotics, anti-endotoxic medications, anti-inflammatory drugs, gastroprotectants, digital cryotherapy, and toxin-binding agents. Seasonal and geographic differences were investigated.

RESULTS

1438 horses from 26 participating hospitals from 5 continents were included. On admission, 65% (926/1419) of horses were administered a fluid bolus. Antimicrobial drugs were administered to 55% (792/1419) within the first 24 hours of admission, with penicillin and gentamicin being the most used combination (25%, 198/792). Horses with leukopenia (OR: 2.264, 95%CI: 1.754 to 2.921; P<0.001) or meeting systemic inflammatory response syndrome criteria (OR: 2.542, 95%CI: 1.919 to 3.368; P<0.001) had higher odds of being administered antimicrobial drugs. Other treatments administered included probiotics (15%, 215/1438), polymyxin B (13%; 187/1438), pentoxifylline (8%; 118/1438), gastroprotectants (44%; 626/1419), digital cryotherapy (34%; 489/1435), plasma transfusion (13%; 182/1410) and toxin-binding agents (36%; 515/1438).

LIMITATIONS

Due to the retrospective nature of the study, the rationale for treatment decisions was unavailable, and associations with survival could not be evaluated.

CONCLUSIONS

Treatments varied between hospitals from different geographic regions. Prospective clinical trials are required to evaluate the effects of various treatments on survival.

摘要

背景

本研究旨在描述和比较全球不同地理区域急性腹泻马的治疗方法。

方法

回顾性收集了 2016 年至 2020 年间参加研究的机构收治的腹泻马的临床资料，包括入院时的液体疗法、抗菌药物、益生菌、抗内毒素药物、抗炎药物、胃保护剂、数字冷冻疗法和毒素结合剂。研究了季节和地理差异。

结果

共纳入来自 5 大洲 26 家参与医院的 1438 匹马。入院时，65%（926/1419）的马接受了液体冲击。抗菌药物在入院后 24 小时内给予 55%（792/1419）的马匹，青霉素和庆大霉素的组合最常用（25%，198/792）。白细胞减少症（OR：2.264，95%CI：1.754 至 2.921；P<0.001）或符合全身炎症反应综合征标准（OR：2.542，95%CI：1.919 至 3.368；P<0.001）的马更有可能接受抗菌药物治疗。其他给予的治疗包括益生菌（15%，215/1438）、多粘菌素 B（13%，187/1438）、己酮可可碱（8%，118/1438）、胃保护剂（44%，626/1419）、数字冷冻疗法（34%，489/1435）、血浆输注（13%，182/1410）和毒素结合剂（36%，515/1438）。