Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
Sci Rep. 2022 Jul 27;12(1):12787. doi: 10.1038/s41598-022-17101-6.
Serum sex hormones are known to be associated with cardiovascular disease (CVD), but effects in healthy men on cardiac function have not been well quantified. The authors sought to evaluate an association of sex hormones with cardiac structure and function. Study participants were 857 Korean men without significant cardiovascular diseases participating in the Healthy Twin Study. We estimated the associations of total testosterone (TT) and sex hormone-binding globulin (SHBG) with cardiac structure and function measured by echocardiography using a linear mixed regression model with consideration of random and fixed effects of covariates. The ratio of peak early diastolic velocity of mitral inflow over peak early diastolic mitral annular velocity (E/e') and left atrial volume index (LAVI), functional parameters reflecting left ventricle (LV) filling pressure, were inversely associated with TT even after further cross-adjustment for SHBG level. There was a positive association between LAVI and SHBG, regardless of TT adjustment. These findings suggest that serum testosterone level is positively associated with LV diastolic function independent of SHBG level.
血清性激素与心血管疾病（CVD）有关，但在健康男性中对心脏功能的影响尚未得到很好的量化。作者旨在评估性激素与心脏结构和功能的关系。研究参与者为 857 名无明显心血管疾病的韩国男性，参加了健康双胞胎研究。我们使用线性混合回归模型，考虑到协变量的随机和固定效应，估计了总睾酮（TT）和性激素结合球蛋白（SHBG）与超声心动图测量的心脏结构和功能之间的关系。反映左心室（LV）充盈压的功能参数，二尖瓣早期舒张速度与二尖瓣环早期舒张速度之比（E/e'）和左心房容积指数（LAVI）与 TT 呈负相关，即使进一步交叉调整 SHBG 水平也是如此。LAVI 与 SHBG 呈正相关，而与 TT 无关。这些发现表明，血清睾丸激素水平与 SHBG 水平无关，与 LV 舒张功能呈正相关。
