Department of Epidemiology, College of Public Health & Health Professions and College of Medicine, University of Florida, Gainesville, Florida, USA.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
JCI Insight. 2024 Oct 15;9(22):e181172. doi: 10.1172/jci.insight.181172.
BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent biracial cohort (65% White, 35% Black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by logistic GEE model in American Indians. Longitudinal associations between changes in lipids and changes in LVMI were examined by GEE, adjusting for baseline lipids, baseline LVMI, and covariates.RESULTSMultiple lipid species were significantly associated with LVMI or the risk of LVH in American Indians. Some lipids were confirmed in Black and White individuals. Moreover, some LVH-related lipids were inversely associated with risk of coronary heart disease (CHD). Longitudinal changes in several lipid species were significantly associated with changes in LVMI.CONCLUSIONAltered fasting plasma lipidome and its longitudinal change over time were significantly associated with LVMI and risk for LVH in American Indians. Our results offer insight into the role of individual lipid species in LV remodeling and risk of LVH, independent of known risk factors.FUNDINGThis study was supported by the NIH grant (R01DK107532). The Strong Heart Study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute, NIH, Department of Health and Human Services, under contract nos. 75N92019D00027, 75N92019D00028, 75N92019D00029, and 75N92019D00030.
左心室肥厚（LVH）和血脂异常是心血管疾病的强有力的独立预测因素，但它们之间的关系尚未得到充分研究。目前尚缺乏左心室质量（LVM）和 LVH 的纵向脂质组学分析。
我们使用液相色谱-质谱（LC-MS）技术，对参加 2 次检查（平均间隔 5 年）的 1755 名美国印第安人中的 1542 种独特的脂质进行了反复测量。通过广义估计方程（GEE）检测个体脂质与左心室质量指数（LVMI）的横断面相关性，然后在一个由 65%白人、35%黑人组成的双种族队列中进行复制。在印第安人中，通过逻辑 GEE 模型确定了基线血浆脂质与传统危险因素以外的 LVH 风险之间的关系。通过 GEE 调整基线脂质、基线 LVMI 和协变量，检测脂质变化与 LVMI 变化之间的纵向关联。
多项脂质与 LVMI 或 LVH 风险显著相关。一些脂质在黑人和白人个体中得到了证实。此外，一些与 LVH 相关的脂质与冠心病（CHD）风险呈负相关。几种脂质的纵向变化与 LVMI 的变化显著相关。
印第安人空腹血浆脂质组及其随时间的纵向变化与 LVMI 和 LVH 风险显著相关。我们的结果提供了有关个体脂质在 LV 重塑和 LVH 风险中的作用的见解，这与已知的危险因素无关。
本研究由美国国立卫生研究院（NIH）资助（R01DK107532）。“强健心脏研究”得到了美国国立心肺血液研究所（NHLBI）、美国国立卫生研究院（NIH）、美国卫生与公众服务部的联邦资金支持，合同号分别为 75N92019D00027、75N92019D00028、75N92019D00029 和 75N92019D00030。
