Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Naples, Italy.
Department of Pediatrics, Division of Endocrinology, British Columbia Children's Hospital and University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
Pediatr Nephrol. 2023 May;38(5):1449-1458. doi: 10.1007/s00467-022-05689-w. Epub 2022 Jul 27.
Children with type 1 diabetes mellitus (T1DM) have an increased risk of developing kidney involvement. Part of the risk establishes at the beginning of T1DM. In fact, up to 65% of children during T1DM onset may experience an acute kidney injury (AKI) which predisposes to the development of a later chronic kidney disease (CKD). The other part of the risk establishes during the following course of T1DM and could be related to a poor glycemic control and the subsequent development of diabetic kidney disease. In this review, we discuss the acute and chronic effects of T1DM on the kidneys, and the implications of these events on the long-term prognosis of kidney function.
患有 1 型糖尿病（T1DM）的儿童患肾脏疾病的风险增加。部分风险在 T1DM 开始时就已存在。事实上，高达 65%的 T1DM 发病儿童可能会经历急性肾损伤（AKI），从而导致后期慢性肾脏病（CKD）的发生。另一部分风险是在 T1DM 的后续病程中形成的，可能与血糖控制不佳和随后发生的糖尿病肾病有关。在这篇综述中，我们讨论了 T1DM 对肾脏的急性和慢性影响，以及这些事件对肾脏功能长期预后的影响。
