Department of Chemistry, Faculty of Natural Science, Mangosuthu University of Technology, Umlazi 4031, KZN, South Africa.
Department of Physics, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Int J Mol Sci. 2022 Jul 23;23(15):8117. doi: 10.3390/ijms23158117.
Heterocyclic compounds are a class of compounds of natural origin with favorable properties and hence have major pharmaceutical significance. They have an exceptional adroitness favoring their use as diverse smart biomimetics, in addition to possessing an active pharmacophore in a complex structure. This has made them an indispensable motif in the drug discovery field. Heterocyclic compounds are usually classified according to the ring size, type, and the number of heteroatoms present in the ring. Among different heterocyclic ring systems, nitrogen heterocyclic compounds are more abundant in nature. They also have considerable pharmacological significance. This review highlights recent pioneering studies in the biological assessment of nitrogen-containing compounds, namely: triazoles, tetrazoles, imidazole/benzimidazoles, pyrimidines, and quinolines. It explores publications between April 2020 and February 2022 and will benefit researchers in medicinal chemistry and pharmacology. The present work is organized based on the size of the heterocyclic ring.
杂环化合物是一类具有优良性质的天然来源化合物，因此具有重要的药物意义。它们具有特殊的灵巧性，除了在复杂结构中具有活性药效团外，还可以作为多种智能仿生药物使用。这使它们成为药物发现领域不可或缺的主题。杂环化合物通常根据环的大小、类型和环中存在的杂原子的数量进行分类。在不同的杂环环系中，含氮杂环化合物在自然界中更为丰富。它们也具有相当大的药理学意义。本综述重点介绍了含氮化合物的生物学评估的最新开创性研究，即：三唑、四唑、咪唑/苯并咪唑、嘧啶和喹啉。它探讨了 2020 年 4 月至 2022 年 2 月之间的出版物，将使药物化学和药理学领域的研究人员受益。本工作根据杂环的大小进行组织。
