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Design and evaluation of novel thiazolidinedione-oxadiazole derivatives as potent α-amylase inhibitors for antidiabetic therapy.

作者信息

Arora Pinky, Rana Aditi, Khan Azmat Ali, Alanazi Amer M, Wadhwa Pankaj, Singla Sonia, Kumar Shubham, Kalra Rubal

机构信息

School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Delhi G.T. Road, Phagwara, Punjab, 144411, India.

School of Healthcare, CT University, Ferozepur Road, Ludhiana, Punjab, 142024, India.

出版信息

J Comput Aided Mol Des. 2025 Jun 27;39(1):38. doi: 10.1007/s10822-025-00619-y.

DOI:10.1007/s10822-025-00619-y
PMID:40576740
Abstract
摘要

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本文引用的文献

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Managing insulin resistance: the forgotten pathophysiological component of type 2 diabetes.管理胰岛素抵抗：2 型糖尿病被遗忘的病理生理学组分。
Lancet Diabetes Endocrinol. 2024 Sep;12(9):674-680. doi: 10.1016/S2213-8587(24)00127-X. Epub 2024 Aug 1.
2
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.青蒿琥酯通过调节代谢谱和MAPK/PI3K/Akt信号通路改善db/db小鼠的糖脂代谢。
Phytomedicine. 2024 Apr;126:155382. doi: 10.1016/j.phymed.2024.155382. Epub 2024 Jan 30.
3
Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes, Kidney Disease, and Hypertension.
高尿酸血症：与代谢综合征、糖尿病、肾病和高血压的有趣关联。
Curr Hypertens Rep. 2024 Jun;26(6):237-245. doi: 10.1007/s11906-024-01295-3. Epub 2024 Jan 25.
4
Recent advances in the treatment of type 2 diabetes mellitus using new drug therapies.新型药物治疗 2 型糖尿病的最新进展。
Kaohsiung J Med Sci. 2024 Mar;40(3):212-220. doi: 10.1002/kjm2.12800. Epub 2024 Jan 6.
5
Synthesis, molecular docking and biological evaluation of 1,2,4-oxadiazole based novel non-steroidal derivatives against prostate cancer.基于 1,2,4-噁二唑的新型非甾体衍生物的合成、分子对接及对前列腺癌的生物评价。
Bioorg Chem. 2024 Feb;143:107029. doi: 10.1016/j.bioorg.2023.107029. Epub 2023 Dec 10.
6
Discovery of Novel Thiazolidinedione-Derivatives with Multi-Modal Antidiabetic Activities In Vitro and In Silico.新型噻唑烷二酮衍生物的发现及其在体外和体内的多模式抗糖尿病活性。
Int J Mol Sci. 2023 Feb 3;24(3):3024. doi: 10.3390/ijms24033024.
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Novel hybrids of thiazolidinedione-1,3,4-oxadiazole derivatives: synthesis, molecular docking, MD simulations, ADMET study, , and anti-diabetic assessment.噻唑烷二酮-1,3,4-恶二唑衍生物的新型杂化物：合成、分子对接、分子动力学模拟、药物代谢动力学/药物毒性研究及抗糖尿病评估
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Bioorg Chem. 2019 Nov;92:103271. doi: 10.1016/j.bioorg.2019.103271. Epub 2019 Sep 10.