Mizuno Takuya, Inoue Misuzu, Kubo Takeaki, Iwaki Yoshihide, Kawamoto Kosuke, Itamoto Kazuhito, Kambayashi Satoshi, Igase Masaya, Baba Kenji, Okuda Masaru
Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo, Japan.
Vet Anim Sci. 2022 Jul 19;17:100264. doi: 10.1016/j.vas.2022.100264. eCollection 2022 Sep.
Nonregenerative anemia is occasionally seen in dogs and can be caused by many factors, among which nonregenerative immune-mediated anemia (NRIMA) and pure red cell anemia are relatively common causes. These are thought to be caused by immune-mediated destruction of the erythroid lineage and are treated with immunosuppressive drugs, but some of them are refractory or recurrent, so new treatments are needed.
To examine the efficacy of allogeneic adipose-derived stem cells (ADSCs) for the treatment of nonregerative anemia in dogs.
ADSCs were administered to total five nonregenerative anemia cases; two NRIMA cases and two suspected NRIMA cases that were refractory to immunosuppressive agents, and one NRIMA case that has not been treated with immunosuppressive agents.
In all cases, anemia was improved, and blood transfusion was no longer necessary.
This study suggests that allogeneic ADSCs may be one of the rescue therapies for the refractory immune-mediated anemia in dogs.
非再生性贫血在犬类中偶尔可见，可由多种因素引起，其中非再生性免疫介导性贫血（NRIMA）和纯红细胞贫血是相对常见的病因。这些被认为是由免疫介导的红系细胞破坏所致，并用免疫抑制药物治疗，但其中一些病例难治或复发，因此需要新的治疗方法。
研究异体脂肪来源干细胞（ADSCs）治疗犬非再生性贫血的疗效。
对总共5例非再生性贫血病例给予ADSCs；2例NRIMA病例、2例对免疫抑制剂难治的疑似NRIMA病例，以及1例未接受免疫抑制剂治疗的NRIMA病例。
所有病例贫血均得到改善，不再需要输血。
本研究表明，异体ADSCs可能是犬难治性免疫介导性贫血的挽救疗法之一。
