Hare Heather, Tiwari Pragya, Baluch Aliyah, Greene John
College of Pharmacy, University of Florida Health, Tampa, USA.
Cardiology, Hridaya Clinic, Delhi, IND.
Cureus. 2022 Jun 24;14(6):e26277. doi: 10.7759/cureus.26277. eCollection 2022 Jun.
This report describes a case of a young man with DiGeorge Syndrome, repaired Tetralogy of Fallot, relapsed metastatic Hodgkin's Lymphoma, immunodeficiency, and a history of recurrent and severe infections. A review of the literature indicates that patients with DiGeorge Syndrome are at greater risk for infection, malignancy, and cardiac events due to anatomic and immunologic complications resulting from a deletion in the 22q11.2 chromosome. As an increased number of patients with DiGeorge Syndrome are surviving into adulthood, it is important to understand the progression of the disease and the long-term implications associated with variable degrees of thymic hypoplasia and immune deficiency.
本报告描述了一名患有迪格奥尔格综合征、法洛四联症修复术后、复发性转移性霍奇金淋巴瘤、免疫缺陷以及有反复严重感染病史的年轻男性病例。文献综述表明，由于22q11.2染色体缺失导致的解剖学和免疫学并发症，迪格奥尔格综合征患者发生感染、恶性肿瘤和心脏事件的风险更高。随着越来越多的迪格奥尔格综合征患者存活至成年，了解该疾病的进展以及与不同程度胸腺发育不全和免疫缺陷相关的长期影响非常重要。
