Zhang Ruonan, Peng Shuang, Zhu Guangxun
Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jpn Dent Sci Rev. 2022 Nov;58:227-232. doi: 10.1016/j.jdsr.2022.07.001. Epub 2022 Jul 22.
The process of bone remodeling is connected with the regulated balance between bone cell populations (including bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte). And the mechanism of bone remodeling activity is related to the major pathway, receptor activator of nuclear factor kappaB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) signaling axis. Recently, researchers have found a novel cytokine secreted by activated T cells, which is related to osteoclastogenesis in the absence of osteoblasts or RANKL, leading to bone destruction. They name it the secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT has been proven to play an essential role in bone remodeling, like mediating the bone resorption in rheumatoid arthritis (RA) and periodontitis. In this review, we outline the latest research concerning SOFAT and discuss the characteristics, location, and regulation of SOFAT. We also summarize the clinical progress of SOFAT and assume the future therapeutic target in some diseases related to bone remodeling.
骨重塑过程与骨细胞群体（包括成骨的成骨细胞、骨吸收的破骨细胞和骨细胞）之间的调节平衡相关。骨重塑活动的机制与主要途径——核因子κB受体激活剂（RANK）/RANK配体（RANKL）/骨保护素（OPG）信号轴有关。最近，研究人员发现了一种由活化T细胞分泌的新型细胞因子，它在没有成骨细胞或RANKL的情况下与破骨细胞生成有关，导致骨质破坏。他们将其命名为活化T细胞分泌的破骨细胞生成因子（SOFAT）。SOFAT已被证明在骨重塑中起重要作用，如介导类风湿性关节炎（RA）和牙周炎中的骨吸收。在这篇综述中，我们概述了关于SOFAT的最新研究，并讨论了SOFAT的特性、定位和调节。我们还总结了SOFAT的临床进展，并设想了其在一些与骨重塑相关疾病中的未来治疗靶点。
