Departments of Neurosurgery, and National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Department of Neonatology, Yale School of Medicine, New Haven, CT, United States.
Front Immunol. 2022 Jul 11;13:924642. doi: 10.3389/fimmu.2022.924642. eCollection 2022.
Epilepsy accounts for a significant proportion of the burden of neurological disorders. Neuroinflammation acting as the inflammatory response to epileptic seizures is characterized by aberrant regulation of inflammatory cells and molecules, and has been regarded as a key process in epilepsy where mTOR signaling serves as a pivotal modulator. Meanwhile, accumulating evidence has revealed that non-coding RNAs (ncRNAs) interfering with mTOR signaling are involved in neuroinflammation and therefore articipate in the development and progression of epilepsy. In this review, we highlight recent advances in the regulation of mTOR on neuroinflammatory cells and mediators, and feature the progresses of the interaction between ncRNAs and mTOR in epileptic neuroinflammation.
癫痫占神经障碍负担的很大一部分。神经炎症是对癫痫发作的炎症反应，其特征是炎症细胞和分子的异常调节，已被认为是癫痫的关键过程，其中 mTOR 信号作为关键调节剂。同时，越来越多的证据表明，干扰 mTOR 信号的非编码 RNA（ncRNA）参与神经炎症，因此参与癫痫神经炎症的发生和发展。在这篇综述中，我们强调了 mTOR 对神经炎症细胞和介质的调节的最新进展，并介绍了 ncRNA 和 mTOR 在癫痫神经炎症中的相互作用的进展。
