Zhou Shanyao, Chen Rui, She Yanling, Liu Xuanjun, Zhao Hui, Li Cheng, Jia Yanbin
Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, 466 Xin Gang Zhong Road, Guangzhou, 510317, China.
Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, 466 Xin Gang Zhong Road, Guangzhou, 510317, China.
J Psychiatr Res. 2022 Apr;148:293-306. doi: 10.1016/j.jpsychires.2022.02.007. Epub 2022 Feb 16.
The high incidence and relapse rate of depression, as well comorbidity with other diseases, has made depression one of the primary causes of years of life lived with disability. Moreover, the unknown biological mechanism of depression has made treatment difficult. Neuroinflammation is important in the pathogenesis of depression. Neuroinflammation may affect depression by regulating the production of immune factors, immune cell activation, neuron generation, synaptic plasticity, and neurotransmission. Non-coding RNAs (ncRNAs) may be a breakthrough link between depression and neuroinflammation, as ncRNAs participate in these biological changes. We summarize the functions and mechanisms of ncRNAs in neuroinflammation and depression, and predict ncRNAs that may regulate the occurrence and progression of depression through neuritis. These findings not only broaden our understanding of the genetic regulation of depression and neuroinflammation but also provide a new perspective of the underlying mechanism and aid in the design of novel prevention, diagnosis, and treatment strategies.
抑郁症的高发病率和复发率，以及与其他疾病的共病现象，使其成为导致多年残疾生活的主要原因之一。此外，抑郁症未知的生物学机制使得治疗困难。神经炎症在抑郁症的发病机制中很重要。神经炎症可能通过调节免疫因子的产生、免疫细胞激活、神经元生成、突触可塑性和神经传递来影响抑郁症。非编码RNA（ncRNAs）可能是抑郁症与神经炎症之间的一个突破性联系，因为ncRNAs参与了这些生物学变化。我们总结了ncRNAs在神经炎症和抑郁症中的功能及机制，并预测了可能通过神经炎调节抑郁症发生和发展的ncRNAs。这些发现不仅拓宽了我们对抑郁症和神经炎症基因调控的理解，还为潜在机制提供了新视角，并有助于设计新的预防、诊断和治疗策略。
