Liu Yuqing, Cheng Xin, Li Hongli, Hui Shan, Zhang Zheyu, Xiao Yang, Peng Weijun
Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Mental Disorder, Changsha, China.
Front Immunol. 2022 Jun 2;13:908076. doi: 10.3389/fimmu.2022.908076. eCollection 2022.
Alzheimer's disease (AD) is one of the most common causes of dementia. Although significant breakthroughs have been made in understanding the progression and pathogenesis of AD, it remains a worldwide problem and a significant public health burden. Thus, more efficient diagnostic and therapeutic strategies are urgently required. The latest research studies have revealed that neuroinflammation is crucial in the pathogenesis of AD. Non-coding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs), PIWI-interacting RNAs (piRNAs), and transfer RNA-derived small RNAs (tsRNAs), have been strongly associated with AD-induced neuroinflammation. Furthermore, several ongoing pre-clinical studies are currently investigating ncRNA as disease biomarkers and therapeutic interventions to provide new perspectives for AD diagnosis and treatment. In this review, the role of different types of ncRNAs in neuroinflammation during AD are summarized in order to improve our understanding of AD etiology and aid in the translation of basic research into clinical practice.
阿尔茨海默病（AD）是痴呆症最常见的病因之一。尽管在理解AD的进展和发病机制方面已取得重大突破，但它仍然是一个全球性问题，也是一项重大的公共卫生负担。因此，迫切需要更有效的诊断和治疗策略。最新的研究表明，神经炎症在AD的发病机制中至关重要。非编码RNA（ncRNA），包括长链非编码RNA（lncRNA）、微小RNA（miRNA）、环状RNA（circRNA）、PIWI相互作用RNA（piRNA）和转运RNA衍生的小RNA（tsRNA），与AD诱导的神经炎症密切相关。此外，目前正在进行的几项临床前研究正在研究ncRNA作为疾病生物标志物和治疗干预手段，为AD的诊断和治疗提供新的视角。在这篇综述中，总结了不同类型的ncRNA在AD神经炎症中的作用，以增进我们对AD病因的理解，并有助于将基础研究转化为临床实践。
