Muhammad T, Irshad C V, Rajan S Irudaya
Department of Family & Generations, International Institute for Population Sciences, Mumbai, 400088, India.
Department of Humanities & Social Sciences, Indian Institute of Technology, Madras, 600036, India.
SSM Popul Health. 2022 Jul 19;19:101175. doi: 10.1016/j.ssmph.2022.101175. eCollection 2022 Sep.
This study explored the association between family history of hypertension and diabetes with their diagnosis among older Indian adults. The study further examined the role of body mass index (BMI) as a potential mediator in these associations.
Data from the Longitudinal Ageing Study in India (LASI, 2017-18), wave-1 were used. The sample for the study included 31,464 older adults aged 60 years and above. Descriptive statistics and bivariate analysis has been conducted to assess the prevalence of self-reported hypertension and diabetes. Further, multivariable logistic regression models were used to test the research hypotheses of this study. The Karlson-Holm-Breen (KHB) mediation analysis was conducted to recover the direct and indirect effects of BMI in the association of family medical history and diagnosis of hypertension and diabetes.
A proportion of 32.70% of older adults were diagnosed with hypertension and 14.23% of older adults were diagnosed with diabetes. A proportion of 19.48% and 14.69% of older adults had a family history of hypertension and diabetes, respectively. Also, 16.57% and 5.53% of older adults were overweight and obese, respectively in the current study. Older adults who had family history of hypertension had higher odds of being diagnosed with hypertension [aOR: 2.23, CI: 2.07-2.39] than those who had no such family history. This association was mediated by BMI (percent mediated: 6.31%). Similarly, older adults who had family history of diabetes had higher odds of being diagnosed with diabetes [aOR: 2.63, CI: 2.41-2.88] than those who had no such family history. This association was mediated by BMI (percent effect mediated: 6.66%).
The study highlights the relevance of using family medical history data along with information on BMI as potential source for the control and management of hypertension and diabetes among older population.
本研究探讨了印度老年成年人中高血压和糖尿病家族史与其诊断之间的关联。该研究进一步考察了体重指数（BMI）作为这些关联中潜在中介因素的作用。
使用了来自印度纵向老龄化研究（LASI，2017 - 18年）第一波的数据。该研究样本包括31464名60岁及以上的老年人。进行了描述性统计和双变量分析以评估自我报告的高血压和糖尿病患病率。此外，使用多变量逻辑回归模型来检验本研究的研究假设。进行了卡尔森 - 霍尔姆 - 布林（KHB）中介分析，以恢复BMI在家族病史与高血压和糖尿病诊断关联中的直接和间接效应。
32.70%的老年人被诊断患有高血压，14.23%的老年人被诊断患有糖尿病。分别有19.48%和14.69%的老年人有高血压和糖尿病家族史。在本研究中，分别有16.57%和5.53%的老年人超重和肥胖。有高血压家族史的老年人被诊断患有高血压的几率高于没有此类家族史的老年人[aOR：2.23，CI：2.07 - 2.39]。这种关联由BMI介导（介导百分比：6.31%）。同样，有糖尿病家族史的老年人被诊断患有糖尿病的几率高于没有此类家族史的老年人[aOR：2.63，CI：2.41 - 2.88]。这种关联由BMI介导（效应介导百分比：6.66%）。
该研究强调了将家族病史数据与BMI信息一起作为老年人群中高血压和糖尿病控制与管理潜在来源的相关性。
