Kuang Wending, Li Yi, Liu Gang, Zhang Yang, Chen Gang, Luo Bang, Kuang Shuangyu
The Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, China.
Department of Diagnosis, Hengyang Medical School, University of South China, Hengyang, China.
Front Surg. 2022 Jul 11;9:930701. doi: 10.3389/fsurg.2022.930701. eCollection 2022.
This study aims to study the correlation between serum β2-glycoprotein I (β2-GPI)/oxidized low-density lipoprotein (oxLDL) and the risk of cerebral infarction in patients with type 2 diabetes (T2DM).
From January 2019 to March 2021, 56 patients with T2DM combined with cerebral infarction were chosen as a diabetic cerebral infarction (DCI) group, and 60 patients with simple T2DM were chosen as a T2DM group. In addition, 60 healthy volunteers were recruited as a control group. The essential information of each group was collected, and the serum β2-GPI/oxLDL and inflammatory factor levels in each group were compared. The clinical factors that affect the risk of ischemic cerebral infarction in patients with T2DM were analyzed by a logistic model.
Compared with the control group, the level of serum β2-GPI/oxLDL in the T2DM and DCI groups increased significantly, < 0.001. Compared with the T2DM group, the serum β2-GPI/oxLDL level in the DCI group increased significantly, < 0.05. The result of correlation analysis showed that serum β2-GPI/oxLDL was positively correlated with total cholesterol, triglycerides, fasting blood glucose, 2-h postprandial blood glucose, glycosylated hemoglobin, interleukin-6, and tumor necrosis factor (TNF)-α (all 's< 0.05). Serum TNF-α and β2-GPI/oxLDL were independent risk variates for DCI (< 0.05). Based on the receiver operating characteristic curve analysis, the values of the area under the curve for TNF-α, serum β2-GPI/oxLDL, and the combined diagnosis of DCI were 0.653 (0.552-0.753), 0.680 (0.583-0.777), 0.739 (0.647-0.831), respectively.
In DCI patients, the levels of serum oxLDL/β2-GPI are significantly increased. Serum oxLDL/β2-GPI is an independent risk factor that affects the occurrence of DCI. In addition, the serum β2-GPI/oxLDL level implicates the lipid metabolism and inflammatory status of the internal environment of DCI patients to a certain extent.
本研究旨在探讨血清β2-糖蛋白I（β2-GPI）/氧化型低密度脂蛋白（oxLDL）与2型糖尿病（T2DM）患者脑梗死风险之间的相关性。
选取2019年1月至2021年3月期间56例T2DM合并脑梗死患者作为糖尿病脑梗死（DCI）组，60例单纯T2DM患者作为T2DM组。另外，招募60名健康志愿者作为对照组。收集各组的基本信息，并比较各组血清β2-GPI/oxLDL及炎症因子水平。采用logistic模型分析影响T2DM患者缺血性脑梗死风险的临床因素。
与对照组相比，T2DM组和DCI组血清β2-GPI/oxLDL水平显著升高，<0.001。与T2DM组相比，DCI组血清β2-GPI/oxLDL水平显著升高，<0.05。相关性分析结果显示，血清β2-GPI/oxLDL与总胆固醇、甘油三酯、空腹血糖、餐后2小时血糖、糖化血红蛋白、白细胞介素-6及肿瘤坏死因子（TNF）-α均呈正相关（所有P<0.05）。血清TNF-α和β2-GPI/oxLDL是DCI的独立危险因素（<0.05）。基于受试者工作特征曲线分析，TNF-α、血清β2-GPI/oxLDL及二者联合诊断DCI的曲线下面积值分别为0.653（0.552-0.753）、0.680（0.583-0.777）、0.739（0.647-0.831）。
在DCI患者中，血清oxLDL/β2-GPI水平显著升高。血清oxLDL/β2-GPI是影响DCI发生的独立危险因素。此外，血清β2-GPI/oxLDL水平在一定程度上反映了DCI患者体内脂质代谢及内环境炎症状态。
