Kanamori Akira, Tominaga Keiichi, Masuyama Hironori, Ishikawa Mutsumi, Masuyama Satoshi, Kondo Masayuki, Kanazawa Mimari, Tanaka Takanao, Yamaura Masamichi, Abe Keiichiro, Watanabe Shoko, Yamamiya Akira, Abe Yoko, Goda Kenichi, Irisawa Atsushi
Department of Gastroenterology Dokkyo Medical University School of Medicine Tochigi Japan.
Masuyama Gastrointestinal Clinic Tochigi Japan.
DEN Open. 2022 Jun 5;3(1):e135. doi: 10.1002/deo2.135. eCollection 2023 Apr.
The patient, a 73-year-old woman, had been taking acid-suppressive therapy for refractory reflux esophagitis for 10 years. A potassium-competitive acid blocker was administered to strengthen acid-suppressive therapy for worsening symptoms of gastroesophageal reflux disease. Esophagogastroduodenoscopy showed an increase in the number and size of fundic gland polyposis (FGPs). When acid-suppressive therapy was changed from potassium-competitive acid blocker to proton pump inhibitor, the FGPs showed reduced size 1 year later. Furthermore, when acid-suppressive therapy was changed from proton pump inhibitor to histamine-2 receptor antagonist, FGPs were even smaller after 1 and 2 years. The patient, who had no flare-up of gastroesophageal reflux disease symptoms, continues to be treated medically with histamine-2 receptor antagonist. This case report describes changes in endoscopic findings of a patient with FGPs caused by acid-suppressive therapy for refractory gastroesophageal reflux disease.
该患者为一名73岁女性，因难治性反流性食管炎接受抑酸治疗已达10年。因胃食管反流病症状加重，给予钾竞争性酸阻滞剂以强化抑酸治疗。食管胃十二指肠镜检查显示胃底腺息肉（FGP）的数量和大小增加。当抑酸治疗从钾竞争性酸阻滞剂改为质子泵抑制剂时，1年后FGP的大小减小。此外，当抑酸治疗从质子泵抑制剂改为组胺-2受体拮抗剂时，1年和2年后FGP变得更小。该患者胃食管反流病症状未复发，继续接受组胺-2受体拮抗剂药物治疗。本病例报告描述了一名因难治性胃食管反流病接受抑酸治疗而出现FGP的患者内镜检查结果的变化。
