Abdelazez Amro, Alshehry Garsa, Algarni Eman, Al Jumayi Huda, Abdel-Motaal Heba, Meng Xiang-Chen
Key Laboratory of Dairy Science, Ministry of Education, College of Food Sciences, Northeast Agricultural University, Harbin, China.
Faculty of Agriculture and Forestry, Institute of Microbe and Host Health, Linyi University, Linyi, China.
Front Microbiol. 2022 Jul 11;13:943930. doi: 10.3389/fmicb.2022.943930. eCollection 2022.
Diabetes is a serious disease that threatens human health worldwide. The study hypothesis is to investigate the novel trends that may aid in the prevention of diabetic complications. Camel milk was presented as traditional functional food, and KLDS and KLDS strains were shown to synthesize postbiotic Gamma-aminobutyric acid as a potential food additive, which can therapeutically intervene against hyperglycemia and hyperlipidemia in streptozotocin-induced CBL/6J mice. During a four-week timeframe, body weight and postprandial blood glucose levels were monitored. Post-euthanasia, blood plasma was obtained to investigate hyperlipidemia, insulin concentrations, liver, and renal functions. The liver, pancreas, kidney, and spleen underwent histopathological examinations. The results demonstrated that KLDS and KLDS ( , ) and camel milk treatments all had a significant influence on hypoglycemic activity, as evidenced by reduced postprandial blood glucose levels. , , and camel milk therapy significantly reduced blood hypolipidemic, and some liver enzymes such as (alanine aminotransferase and aspartate transaminase) levels. Therefore, we recommend consuming camel milk regularly and expanding its use with fermented foods containing , one of the probiotics capable of producing gamma-aminobutyric acid (GABA) as future food additives that can improve human health and reduce the prevalence of several diseases disorders.
糖尿病是一种严重威胁全球人类健康的疾病。该研究假设是调查可能有助于预防糖尿病并发症的新趋势。骆驼奶被视为传统功能性食品，并且KLDS和KLDS菌株被证明能合成益生元γ-氨基丁酸作为一种潜在的食品添加剂，其可对链脲佐菌素诱导的C57BL/6J小鼠的高血糖和高血脂进行治疗性干预。在为期四周的时间内，监测体重和餐后血糖水平。安乐死后，获取血浆以研究高血脂、胰岛素浓度、肝脏和肾脏功能。对肝脏、胰腺、肾脏和脾脏进行组织病理学检查。结果表明，KLDS和KLDS（ ， ）以及骆驼奶治疗对降血糖活性均有显著影响，餐后血糖水平降低即为证明。 ， 以及骆驼奶疗法显著降低了血脂，并且降低了一些肝酶如（丙氨酸转氨酶和天冬氨酸转氨酶）水平。因此，我们建议定期饮用骆驼奶，并扩大其与含有 （能够产生γ-氨基丁酸（GABA）的益生菌之一）的发酵食品的搭配使用，作为未来可改善人类健康并降低多种疾病患病率的食品添加剂。
