Deitel M, Petrov I
Surg Gynecol Obstet. 1987 Jun;164(6):549-52.
Incidence of gallstones in morbidly obese patients and further development of symptomatic gallstones with weight loss after bariatric operations were studied. Of the 552 patients with mean preoperative weight 210.4 per cent of ideal, jejunoileal bypass has been performed upon 63, horizontal gastric partitioning in 184 and vertical banded gastroplasty in 305. Cholecystectomy had been done previously upon 146 patients (26.4 per cent). A further 67 patients (12.1 per cent) underwent cholecystectomy at the time of bariatric surgical treatment for diagnosed gallstones. The remaining 339 patients at risk of having cholelithiasis develop after a bariatric operation have been observed for more than one to 12 years; symptomatic gallstones requiring cholecystectomy developed in 39. Of these 339 patients, 17 had the symptomatic gallstones in the first year, 17 in the second year and only five from two to 12 years postoperatively. The pathologic type of stone was cholesterol in 87 per cent and mixed in 13 per cent (the latter were patients who underwent jejunoileal bypasses). In the 339 patients, 280 had lost greater than or equal to 50 per cent and 59 had lost less than 50 per cent of excess weight; symptomatic gallstones developed in 33 of the 280 in the former group and six of the 59 in the latter (p = 0.06). Although no complications resulted, concomitant cholecystectomy was often difficult in these massively obese patients, whereas cholecystectomy after weight loss has been relatively easy. Routine cholecystectomy at the time of these operations does not appear justified.
对病态肥胖患者胆结石的发病率以及减肥手术后体重减轻时症状性胆结石的进一步发展情况进行了研究。在552例术前平均体重为理想体重210.4%的患者中,63例行空肠回肠旁路术,184例行水平胃分隔术,305例行垂直捆绑胃成形术。146例患者(26.4%)此前已行胆囊切除术。另外67例患者(12.1%)在减肥手术治疗时因诊断为胆结石而接受了胆囊切除术。其余339例有减肥手术后发生胆石症风险的患者被观察了1至12年以上;39例出现了需要行胆囊切除术的症状性胆结石。在这339例患者中,17例在第一年出现症状性胆结石,17例在第二年出现,术后两年至12年仅有5例出现。结石的病理类型87%为胆固醇结石,13%为混合性结石(后者为行空肠回肠旁路术的患者)。在339例患者中,280例体重减轻超过或等于50%,59例体重减轻不足50%;前一组280例中有33例出现症状性胆结石,后一组59例中有6例出现(p = 0.06)。虽然没有出现并发症,但在这些极度肥胖的患者中,同期行胆囊切除术往往很困难,而体重减轻后行胆囊切除术相对容易。在这些手术时常规行胆囊切除术似乎没有道理。