Wang J N, Li T T, Fang J L, Tang S, Zhang Y, Deng F C, Shen C, Shi W Y, Liu Y Y, Chen C, Sun Q H, Wang Y W, Du Y J, Dong H R, Shi X M
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Jul 6;56(7):897-901. doi: 10.3760/cma.j.cn112150-20220525-00527.
To explore the association between short-term exposures to fine particulate matter (PM) on blood lipids in the elderly. In this panel study, five repeated measurements were performed on 76 people aged 60-69 in Jinan city. Each participant had a PM monitor for 72 hours before each health examination, including a questionnaire survey, physical examination, and biological sample collection. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were examined, and non-HDL-C concentrations were calculated by subtracting HDL-C from TC. The generalized linear mixed-effects model was used to quantify the association of personal PM exposure at different lag with blood lipids and dyslipidemia. The age of 70 participants was (65.0±2.8) years, of which 48.6% (34/70) were males. The BMI of participants was (25.0±2.5) kg/m. Their TC, TG, LDL-C, HDL-C, and non-HDL-C concentrations were (5.75±1.32), (1.55±0.53), (3.27±0.94), (1.78±0.52), and (3.97±1.06) mmol/L, respectively. Generalized linear mixed-effects model showed that after adjusting for confounding factors, at lag 72 hours, each 10 μg/m increase in PM was associated with the percentage change in TC, LDL-C, HDL-C and non-HDL-C about 1.77% (95%: 1.22%-2.32%), 1.90% (95%: 1.18%-2.63%), 1.99% (95%: 1.37%-2.60%) and 1.74% (95%: 1.11%-2.37%), and the OR values (95%) of hypercholesterolemia, hypertriglyceridemia and hyperbetalipoproteinemia were 1.11 (1.01-1.22), 1.33 (1.03-1.71) and 1.15 (1.01-1.31), respectively. There is a significant association of short-term PM exposure with the concentration of blood lipids and the risk of dyslipidemia in the elderly.
探讨老年人短期暴露于细颗粒物（PM）与血脂之间的关联。在这项队列研究中，对济南市76名60 - 69岁的老年人进行了五次重复测量。每位参与者在每次健康检查前佩戴PM监测仪72小时，检查内容包括问卷调查、体格检查和生物样本采集。检测血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL - C）和低密度脂蛋白胆固醇（LDL - C），并通过TC减去HDL - C计算非HDL - C浓度。采用广义线性混合效应模型量化不同滞后时间的个人PM暴露与血脂及血脂异常之间的关联。70名参与者的年龄为（65.0±2.8）岁，其中48.6%（34/70）为男性。参与者的BMI为（25.0±2.5）kg/m²。他们的TC、TG、LDL - C、HDL - C和非HDL - C浓度分别为（5.75±1.32）、（1.55±0.53）、（3.27±0.94）、（1.78±0.52）和（3.97±1.06）mmol/L。广义线性混合效应模型显示，在调整混杂因素后，在滞后72小时时，PM每增加10 μg/m³，TC、LDL - C、HDL - C和非HDL - C的百分比变化分别约为1.77%（95%：1.22% - 2.32%）、1.90%（95%：1.18% - 2.63%）、1.99%（95%：1.37% - 2.60%）和1.74%（95%：1.11% - 2.37%），高胆固醇血症、高甘油三酯血症和高β脂蛋白血症的OR值（95%）分别为1.11（1.01 - 1.22）、1.33（1.03 - 1.71）和1.15（1.01 - 1.31）。老年人短期PM暴露与血脂浓度及血脂异常风险之间存在显著关联。
