Li M M, Yuan D F, Liu Y X, Liu Y B, Wang Bei
Department of Epidemiology and Health Statistics, Southeast University School of Public Health, Nanjing 210009, China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Jul 6;56(7):994-1003. doi: 10.3760/cma.j.cn112150-20220402-00313.
To systematically analyze the IgG seroprevalence of mumps virus (MuV) in Chinese healthy population, and evaluate the immune effect based on the immunization strategy and the incidence of mumps in China. The databases of Wanfang data knowledge service platform, China National Knowledge Infrastructure, SinoMed, PubMed, and Web of Science were searched to retrieve literature about the level of MuV IgG antibody in Chinese healthy population from January 1, 2000, to March 31, 2022. The quality of eligible papers was appraised by using the cross-sectional study evaluation tool from Joanna Briggs Institute. Data analysis, including the stratified analysis of the IgG seroprevalence in different generations, regions, gender, immunization status, and age groups, was performed using R 4.1.2 and Stata 16.0. A total of 69 papers (66 in Chinese and 3 in English) were included, involving 97 034 people in 26 administrative regions across China. The results showed that the MuV IgG seroprevalence in Chinese healthy population was 74.87% (95%: 71.41%-78.17%) and increased over time according to the cumulative Meta-analysis. The geometric mean concentration of antibody was 177.83 U/ml. The subgroup analysis showed that the positive rate of MuV IgG antibody increased with the age and vaccination doses. The positive rate of antibody in children aged from 0 to 17 months was only 32.42% (95%: 25.96%-38.88%). The highest positive rate was reported in North China, about 81.45% (95%: 75.76%-87.14%). In addition, the positive rate of MuV IgG antibody in urban population was higher than that in rural population (<0.01) and the positive rate of MuV IgG antibody in women was higher than that in men (<0.01). Since the vaccine was included in the expanded immunization program, the positive rate of mumps antibody in China has increased, and the antibody level varies in different regions and populations. It is still necessary to improve the MuV antibody level in Chinese healthy population, so as to better prevent and control the mumps epidemic in the future.
系统分析中国健康人群中腮腺炎病毒（MuV）的IgG血清流行率，并根据免疫策略和中国腮腺炎发病率评估免疫效果。检索万方数据知识服务平台、中国知网、中国生物医学文献数据库、PubMed和Web of Science数据库，以获取2000年1月1日至2022年3月31日期间关于中国健康人群中MuV IgG抗体水平的文献。使用乔安娜·布里格斯研究所的横断面研究评估工具对符合条件的论文质量进行评估。使用R 4.1.2和Stata 16.0进行数据分析，包括对不同年代、地区、性别、免疫状况和年龄组的IgG血清流行率进行分层分析。共纳入69篇论文（66篇中文和3篇英文），涉及中国26个行政区的97034人。结果显示，根据累积Meta分析，中国健康人群中MuV IgG血清流行率为74.87%（95%：71.41%-78.17%），且随时间增加。抗体几何平均浓度为177.83 U/ml。亚组分析显示，MuV IgG抗体阳性率随年龄和接种剂量增加而升高。0至17个月儿童的抗体阳性率仅为32.42%（95%：25.96%-38.88%）。华北地区报告的阳性率最高，约为81.45%（95%：75.76%-87.14%）。此外，城市人群中MuV IgG抗体阳性率高于农村人群（<0.01），女性中MuV IgG抗体阳性率高于男性（<0.01）。自疫苗纳入扩大免疫规划以来，中国腮腺炎抗体阳性率有所提高，且抗体水平在不同地区和人群中存在差异。仍有必要提高中国健康人群的MuV抗体水平，以便更好地预防和控制未来的腮腺炎疫情。
