分析 29 例磷化氢中毒患者总磷化氢分布及中毒特征。

Analysis of the Distribution of Total Phosphine and the Characteristics of Phosphine Poisoning in 29 Victims.

机构信息

Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Institute of Criminal Science and Technology, Jiading Branch of Shanghai Public Security Bureau, Shanghai 201800, China.

出版信息

Fa Yi Xue Za Zhi. 2022 Apr 25;38(2):254-257. doi: 10.12116/j.issn.1004-5619.2020.300901.

DOI:10.12116/j.issn.1004-5619.2020.300901

PMID:35899515

Abstract

OBJECTIVES

To study the distribution of total phosphine in phosphine poisoning victims and summarize the characteristics of phosphine poisoning cases.

METHODS

The phosphine and its metabolites in the biological samples of 29 victims in 16 phosphine poisoning cases were qualified and quantified by headspace gas chromatography-mass spectrometry.

RESULTS

Five victims among 29 were poisoned by ingestion of aluminium phosphide and 24 by inhalation of phosphine gas. Phosphine metabolites were detected in the biological samples of 23 victims, and the concentrations of total phosphine in blood ranged 0.5-34.0 μg/mL. The total concentration of phosphine in liver tissue was up to 71.0 μg/g. Phosphine was not detected in the blood of the other six survived victims, which may be related to the small amount of phosphine exposure and the delay in blood sampling.

CONCLUSIONS

The total concentration of phosphine in blood and tissues caused by aluminum phosphine ingestion is higher than that caused by phosphine gas inhalation. The death cases of phosphine inhalation are characterized by long exposure time, repeated exposures and age susceptibility.

摘要

目的

研究磷化氢中毒受害者体内总磷化氢的分布情况，总结磷化氢中毒病例的特点。

方法

采用顶空气相色谱-质谱法对 16 例磷化氢中毒患者 29 名受害者的生物样本中的磷化氢及其代谢物进行定性和定量。

结果

在 29 名受害者中，有 5 名因摄入磷化铝而中毒，24 名因吸入磷化氢气体而中毒。在 23 名受害者的生物样本中检测到了磷化氢代谢物，血液中总磷化氢浓度为 0.5-34.0μg/ml。肝组织中总磷含量高达 71.0μg/g。其余 6 名幸存受害者的血液中未检测到磷化氢，这可能与接触磷化氢的量较小以及血液采集时间延迟有关。