State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, China.
School of Environment and Life Science, College of Chemistry and Materials, Nanning Normal University, Nanning, 530001, China.
Angew Chem Int Ed Engl. 2022 Sep 19;61(38):e202208570. doi: 10.1002/anie.202208570. Epub 2022 Aug 11.
Targeting metabolic reprogramming to treat cancer could increase overall survival and reduce side effects. Here, we put forward a strategy using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming. Complexes 1-6 with oxoglaucine derivatives as ligands were synthesized and their anti-tumor activities were tested under hypoglycemia. Results indicated that 2 and 5 potentiated the anticancer effects of Met. under hypoglycemia, exhibiting lower toxicity, slower blood glucose decline and inhibition of early tumor liver metastasis. Combination of 5 with Met. could be used as a new strategy to treat cancer under hypoglycemia through glucose metabolism reprogramming.
靶向代谢重编程治疗癌症可以提高整体存活率并降低副作用。在这里，我们提出了一种使用芳烃-钌(II)/锇(II)配合物通过葡萄糖代谢重编程来增强二甲双胍（Met.）抗癌作用的策略。合成了带有氧钛菁衍生物作为配体的配合物 1-6，并在低血糖条件下测试了它们的抗肿瘤活性。结果表明，2 和 5 在低血糖条件下增强了 Met. 的抗癌作用，表现出较低的毒性、较慢的血糖下降和早期肿瘤肝转移的抑制作用。将 5 与 Met. 联合使用可以作为通过葡萄糖代谢重编程在低血糖下治疗癌症的新策略。
