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氧化青藤碱在治疗人类疾病医学中的生物学潜力:药理活性及相关分子机制的最新进展

Biological Potential of Oxoglaucine in Medicine for the Treatment of Human Disorders: An Update on Pharmacological Activities and Related Molecular Mechanism.

作者信息

Patel Kanika, Patel Dinesh Kumar

机构信息

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, Uttar Pradesh, India.

出版信息

Recent Adv Antiinfect Drug Discov. 2025;20(2):77-91. doi: 10.2174/0127724344297762240815073618.

Abstract

Medicinal plants are an integral part of the medical system in many countries around the world. Natural products have been used as important biological sources for drug discovery over the past half-century. Alkaloids are a group of natural compounds that contain a basic nitrogen atom. Oxoglaucine is a phytochemical of the oxoaporphines class phytochemical isolated from Maxim, , and . The purpose of this study is to analyze all the scientific information about oxoglaucine in order to know the health-beneficial potential of oxoglaucine in medicine. The detailed pharmacological activities of oxoglaucine are analyzed and discussed in this review. The scientific data of the present review about oxoglaucine were collected from PubMed, Scopus, Science Direct, and Google using the terms oxoglaucine, oxoaporphines, alkaloid, phytochemical, pharmacological, and herbal medicine. The scientific findings of the present review article describe the biological importance and therapeutic effectiveness of oxoglaucine in medicine. The present article scientific data signified the biological potential of oxoglaucine against inflammatory diseases, arthritis, osteoarthritis, immune response, enterovirus, and poliovirus. Furthermore, its anticancer, antiaggregation, antifungal, antiprotozoal, and cytotoxic potential are also described in this review article. The scientific information in this article will be helpful to all the scientific peoples of biological science to understand the therapeutic potential of oxoglaucine in medicine.

摘要

药用植物是世界上许多国家医疗体系中不可或缺的一部分。在过去的半个世纪里,天然产物一直是药物发现的重要生物来源。生物碱是一类含有碱性氮原子的天然化合物。氧化青藤碱是从[植物名称未完整给出]中分离出的氧阿朴啡类植物化学物质。本研究的目的是分析所有关于氧化青藤碱的科学信息,以便了解其在医学上的健康有益潜力。本文对氧化青藤碱的详细药理活性进行了分析和讨论。本综述中关于氧化青藤碱的科学数据是从PubMed、Scopus、Science Direct和谷歌收集的,使用的关键词有氧化青藤碱、氧阿朴啡、生物碱、植物化学物质、药理学和草药。本综述文章的科学发现描述了氧化青藤碱在医学上的生物学重要性和治疗效果。本文的科学数据表明氧化青藤碱对炎症性疾病、关节炎、骨关节炎、免疫反应、肠道病毒和脊髓灰质炎病毒具有生物学潜力。此外,本综述文章还描述了其抗癌、抗聚集、抗真菌、抗原虫和细胞毒性潜力。本文中的科学信息将有助于所有生物科学领域的科研人员了解氧化青藤碱在医学上的治疗潜力。

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