无过渡金属条件下用于构建C-N键的脱水交叉偶联反应
Dehydrative Cross-Coupling for C-N Bond Construction under Transition-Metal-Free Conditions.
作者信息
Xing Huicong, Chen Meijuan, Zhang Dong, Geng Zhishuai, Xie Peizhong, Loh Teck-Peng
机构信息
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P.R. China.
National Engineering Research Center of Flame Retardant Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, P.R. China.
出版信息
Org Lett. 2022 Aug 12;24(31):5657-5662. doi: 10.1021/acs.orglett.2c01902. Epub 2022 Jul 28.
A transition-metal-free catalytic system was designed to address the dehydrative cross-coupling of unactivated primary/secondary alcohols with amines/amides under environmentally benign conditions. Mg and counteranion (PF) worked synergistically to realize C-OH bond cleavage and concomitant C-N bond formation. A wide range of allylic alcohols and amines/amides were tolerated well in this transformation, which allowed C-N bond construction with high efficiency.
设计了一种无过渡金属催化体系，用于在环境友好的条件下实现未活化的伯醇/仲醇与胺/酰胺的脱水交叉偶联反应。镁和抗衡阴离子（PF）协同作用，实现C-OH键的断裂并同时形成C-N键。在该转化反应中，多种烯丙醇和胺/酰胺都具有良好的耐受性，从而能够高效地构建C-N键。
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