Químico farmacéutico independiente, Concepción, Chile.
Unidad de Farmacia, Farmacovigilancia, Hospital Guillermo Grant Benavente, Concepción, Chile.
Arch Argent Pediatr. 2022 Aug;120(4):257-263. doi: 10.5546/aap.2022.eng.257. Epub 2022 May 27.
Pediatric poisoning is a public health problem worldwide. The objective of this study was to establish the characteristics of pediatric cases of poisoning seen at the pediatric intensive care unit (PICU) of a hospital in Chile.
The medical records of patients diagnosed with poisoning and admitted to the PICU between 2013 and 2017 were reviewed.
A total of 105 cases were identified, who account for 3% of all admissions recorded in the study period. Patients' median age was 10 years. In total, 73.3% of cases were female patients; 51% of cases were associated with intentional poisoning; and 83% were caused by drug exposure. The most common drugs identified were antidepressants (11.2%) and non-steroidal anti-inflammatory drugs (10.7%). Intake was the most frequent route of exposure (93%). The average length of stay in the PICU was 1.3 days. One patient required intubation and another required hemodialysis in the PICU. Statistically significant relationships were established between patient sex and the circumstance of exposure and between the patient's psychiatric condition and the number of toxic substances ingested.
Most poisoning cases seen at the PICU were intentional and occurred in female patients, who had a psychiatric condition. The most common drugs identified were antidepressants and non-steroidal anti-inflammatory drugs.
儿科中毒是一个全球性的公共卫生问题。本研究的目的是确定在智利一家医院的儿科重症监护病房（PICU）中见到的儿科中毒病例的特征。
回顾了 2013 年至 2017 年间被诊断为中毒并收入 PICU 的患者的病历。
共确定了 105 例病例，占研究期间所有入院病例的 3%。患者的中位年龄为 10 岁。共有 73.3%的病例为女性患者；51%的病例为故意中毒；83%是由药物暴露引起的。最常见的药物是抗抑郁药（11.2%）和非甾体抗炎药（10.7%）。摄入是最常见的暴露途径（93%）。PICU 平均住院时间为 1.3 天。1 名患者需要在 PICU 进行插管，另 1 名患者需要进行血液透析。患者的性别与暴露环境之间以及患者的精神状态与摄入的有毒物质数量之间存在统计学上的显著关系。
PICU 中看到的大多数中毒病例都是故意的，发生在有精神病史的女性患者中。最常见的药物是抗抑郁药和非甾体抗炎药。
