Department of Psychiatry, College of Health Science, Mettu University, Mettu, Ethiopia.
Department of Psychiatry, School of Nursing and Midwifery, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
PLoS One. 2022 Jul 28;17(7):e0271713. doi: 10.1371/journal.pone.0271713. eCollection 2022.
Inadequate adherence to treatment is among the main underlying causes of depression becoming a chronic problem. In developing countries due to limited access to health care, inaccurate diagnoses, and scarcity of medications, poor adherence may become an even larger obstacle in the treatment of depression. The current study aims to assess the magnitude and factors related to treatment non-adherence among patients with depressive disorders.
To assess the magnitude and factors associated with treatment non adherence among patients with depressive disorders at St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019.
A hospital-based cross-sectional study was conducted among 415 respondents using systematic random sampling technique. Medication adherence was assessed by using Medication Adherence Rating Scale. Data was entered to Epi-data version 3.1 and analyzed using SPSS version 20. Binary logistic analysis was done and P-values less than 0.05 were considered statistically significant.
The prevalence of treatment non-adherence among patients with depressive disorders was 26% (95%CI; 21.2, 32.5). Previous suicide attempt (AOR = 3.05, 95%CI; 1.82, 5.12), medication side effects (AOR = 2.46, 95%CI; 1.47, 4.11), moderate to high self-stigma (AOR = 2.60, 95%CI; 1.45, 4.66), and poor quality of life (AOR = 2.47, 95%CI; 1.42, 4.28) were significantly associated with treatment non-adherence among patients with depressive disorders.
Treatment non-adherence is a common problem among patients being treated for depressive disorders. Previous suicide attempts, medication side effects, moderate to high self-stigma, and poor quality of life were significantly associated with treatment non-adherence. Appropriate interventions should be developed to promote measures to facilitate adherence in this group of patients, and address the associated factors when applicable.
治疗依从性不足是导致抑郁症成为慢性问题的主要潜在原因之一。在发展中国家，由于获得医疗保健的机会有限、诊断不准确以及药物短缺，治疗依从性较差可能成为抑郁症治疗中的一个更大障碍。本研究旨在评估埃塞俄比亚亚的斯亚贝巴圣安曼精神专科医院抑郁障碍患者治疗不依从的程度和相关因素。
评估 2019 年埃塞俄比亚亚的斯亚贝巴圣安曼精神专科医院抑郁障碍患者治疗不依从的程度和相关因素。
采用系统随机抽样技术，对 415 名受访者进行了基于医院的横断面研究。使用药物依从性评定量表评估药物依从性。数据输入 EpiData 版本 3.1 并使用 SPSS 版本 20 进行分析。进行二项逻辑分析，P 值小于 0.05 被认为具有统计学意义。
抑郁障碍患者治疗不依从的发生率为 26%（95%CI；21.2，32.5）。既往自杀未遂（AOR = 3.05，95%CI；1.82，5.12）、药物副作用（AOR = 2.46，95%CI；1.47，4.11）、中重度自我污名化（AOR = 2.60，95%CI；1.45，4.66）和生活质量差（AOR = 2.47，95%CI；1.42，4.28）与抑郁障碍患者治疗不依从显著相关。
治疗不依从是接受抑郁障碍治疗患者的常见问题。既往自杀未遂、药物副作用、中重度自我污名化和生活质量差与治疗不依从显著相关。应制定适当的干预措施，促进这组患者的依从性措施，并在适用时解决相关因素。
