Chanie Gashaw Sisay, Belachew Eyayaw Ashete, Limenh Liknaw Workie, Beyna Alemante Tafese, Mengesha Assefa Kebad, Bayleyegn Zemenu Wube, Melese Mihret, Azanaw Jember, Sendekie Ashenafi Kibret, Simegn Wudneh
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Sci Rep. 2025 Aug 14;15(1):29775. doi: 10.1038/s41598-025-15102-9.
Non-adherence to antidepressant medication is a well-established factor contributing to treatment failure among patients with major depressive disorder. Addressing this issue is crucial not only for enhancing individual patient outcomes but also for alleviating the broader public health burden. The study aimed to assess antidepressant medication non-adherence and its determinants among patients with major depressive disorder at public hospital psychiatric clinics in Ethiopia. Between June 12, 2024, and November 13, 2024, a multicenter cross-sectional study was conducted at public hospital psychiatric clinics in Ethiopia. Antidepressant non-adherence was assessed using a self-reported tablet count tool with pharmacy refill records available in patients' charts at the time of the interview. The severity of adverse drug reactions (ADRs) was evaluated using the Antidepressant Side-Effect Checklist (ASEC), while the Naranjo ADR Probability Scale was employed to determine the likelihood of ADRs. Data analysis was performed using SPSS version 26.0. Frequencies and percentages, were used to describe the characteristics of study participants. For factors associated with antidepressant non-adherence, multivariate logistic regression was conducted. The association between explanatory variable and non-adherence was assessed using odds ratios (ORs) with 95% CIs. The prevalence of antidepressant medication non-adherence was 139 (32.9%). Female gender [AOR = 3.29, 95% CI (2.04, 5.31)], illiteracy [AOR = 2.17, 95% CI (1.35, 3.50)], unemployment [AOR = 3.40, 95% CI (2.15, 5.38)], treatment duration greater than 25 months [AOR = 1.89, 95% CI (1.05, 3.41)], and severe ADRs [AOR = 3.94, 95% CI (1.68, 9.23)] were significantly associated with Antidepressant medication non-adherence. Being female, illiterate, unemployed, having a treatment duration of more than 25 months, and experiencing severe adverse drug reactions were significantly associated with non-adherence. These findings highlight the need for targeted interventions to improve adherence among these high-risk groups.
不坚持服用抗抑郁药物是导致重度抑郁症患者治疗失败的一个公认因素。解决这个问题不仅对提高个体患者的治疗效果至关重要，而且对减轻更广泛的公共卫生负担也很关键。该研究旨在评估埃塞俄比亚公立医院精神科诊所中重度抑郁症患者的抗抑郁药物不依从情况及其决定因素。在2024年6月12日至2024年11月13日期间，在埃塞俄比亚的公立医院精神科诊所进行了一项多中心横断面研究。使用自我报告的药片计数工具并结合访谈时患者病历中的药房配药记录来评估抗抑郁药物不依从情况。使用抗抑郁药物副作用清单（ASEC）评估药物不良反应（ADR）的严重程度，同时使用纳伦霍药物不良反应概率量表来确定药物不良反应的可能性。使用SPSS 26.0版进行数据分析。频率和百分比用于描述研究参与者的特征。对于与抗抑郁药物不依从相关的因素，进行了多变量逻辑回归分析。使用比值比（OR）和95%置信区间（CI）评估解释变量与不依从之间的关联。抗抑郁药物不依从的患病率为139例（32.9%）。女性[AOR = 3.29，95% CI（2.04，5.31）]、文盲[AOR = 2.17，95% CI（1.35，3.50）]、失业[AOR = 3.40，95% CI（2.15，5.38）]、治疗时间超过25个月[AOR = 1.89，95% CI（1.05，3.41）]以及严重药物不良反应[AOR = 3.94，95% CI（1.68，9.23）]与抗抑郁药物不依从显著相关。女性、文盲、失业、治疗时间超过25个月以及经历严重药物不良反应与不依从显著相关。这些发现凸显了针对这些高危群体进行有针对性干预以提高依从性的必要性。
