Schmidt Nicole L, Brooker Rebecca J, Carroll Ian C, Gagne Jeffrey R, Luo Zhan, Planalp Elizabeth M, Sarkisian Katherine L, Schmidt Cory K, Van Hulle Carol A, Lemery-Chalfant Kathryn, Goldsmith H H
University of Wisconsin-Madison, Waisman Center, Madison, WI, USA.
Texas A&M University, Department of Psychological and Brain Sciences, College Station, TX, USA.
Twin Res Hum Genet. 2019 Aug;22(4):233-239. doi: 10.1017/thg.2019.55.
The Wisconsin Twin Project comprises multiple longitudinal studies that span infancy to early adulthood. We summarize recent papers that show how twin designs with deep phenotyping, including biological measures, can inform questions about phenotypic structure, etiology, comorbidity, heterogeneity, and gene-environment interplay of temperamental constructs and mental and physical health conditions of children and adolescents. The general framework for investigations begins with rich characterization of early temperament and follows with study of experiences and exposures across childhood and adolescence. Many studies incorporate neuroimaging and hormone assays.
威斯康星双胞胎项目包含多项从婴儿期到成年早期的纵向研究。我们总结了近期的论文，这些论文展示了采用深度表型分析（包括生物学测量）的双胞胎设计如何为有关儿童和青少年气质结构、病因、共病、异质性以及基因 - 环境相互作用等问题提供信息，以及如何为儿童和青少年的心理健康状况提供信息。调查的总体框架始于对早期气质的丰富特征描述，随后是对儿童期和青少年期经历及接触情况的研究。许多研究纳入了神经影像学和激素检测。
