涉及三个基因座的连锁不平衡。

Linkage disequilibrium involving three loci.

作者信息

Green J, Woodrow J C

出版信息

Tissue Antigens. 1987 Jan;29(1):18-20. doi: 10.1111/j.1399-0039.1987.tb01544.x.

DOI:10.1111/j.1399-0039.1987.tb01544.x

Abstract

A formula for the estimation of "three-locus interaction delta" given by Nijenhuis & D'Amaro (1985) is considered and found to be unsatisfactory. An alternative symmetrical formula is given. Other features of the analysis of Nijenhuis & D'Amaro are criticized and it is emphasized that a more suitable method of analysis of interactions of different orders is given by the use of the empirical logistic method (Green et al. 1983).

摘要

我们考虑了由尼延huis和达马罗（1985年）给出的用于估计“三位点相互作用增量”的公式，发现该公式并不令人满意。我们给出了一个替代的对称公式。我们批评了尼延huis和达马罗分析的其他特征，并强调使用经验逻辑方法（格林等人，1983年）可以给出一种更合适的不同阶次相互作用分析方法。