Wood B G, Keough E M
Tissue Cell. 1987;19(2):235-41. doi: 10.1016/0040-8166(87)90008-5.
A detailed study of the anterior pituitaries of pregnant and lactating mice revealed changes occurring in the ultrastructure of the somatotrophs. The rough endoplasmic reticulum cisternae become greatly dilated forming channels that are continuous with the perivascular space. This occurrence expands the membrane surface available for the release of hormone. Individual granules and cytoplasmic islands containing numerous granules appear in these channels. This suggests an alternative mechanism for granule release which would facilitate a rapid response to increased hormone requirement.
对怀孕和哺乳期小鼠垂体前叶的详细研究揭示了生长激素细胞超微结构中发生的变化。粗面内质网池显著扩张，形成与血管周隙相连的通道。这种情况扩大了可供激素释放的膜表面积。在这些通道中出现了单个颗粒以及含有大量颗粒的细胞质岛。这提示了一种颗粒释放的替代机制，该机制将有助于对激素需求增加做出快速反应。
