Peters L L, Wood B G, Grimm J K
Department of Zoology, University of Maine, Orono 04469.
Tissue Cell. 1989;21(1):11-5. doi: 10.1016/0040-8166(89)90016-5.
An ultrastructural study of the anterior pituitaries of cycling rats reveals changes in the ultrastructure of the gonadotrophs during the afternoon of proestrus when the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) is high. The rough endoplasmic reticulum cisternae become greatly dilated, forming extensive channels which are continuous with the perivascular space and provide an increased surface for the release of hormones. Granules and cytoplasmic islands of granules are seen in these spaces. Such changes are not observed during diestrus and early proestrus when the release of FSH/LH is low. The data indicate that intracisternal granule formation is an important mechanism by which anterior pituitary cells respond to increased hormonal requirements.
对处于发情周期的大鼠垂体前叶进行的超微结构研究显示，在发情前期下午，当促卵泡激素（FSH）和促黄体生成素（LH）释放量较高时，促性腺激素细胞的超微结构会发生变化。粗面内质网池显著扩张，形成与血管周围间隙相连的广泛通道，为激素释放提供了更大的表面。在这些间隙中可见颗粒及颗粒状细胞质岛。在动情间期和发情前期早期，当FSH/LH释放量较低时，未观察到此类变化。数据表明，池内颗粒形成是垂体前叶细胞应对激素需求增加的一种重要机制。
