Gerhards H
Tierarztl Prax. 1987;15(1):47-55.
Antithrombin III (AT III) determinations were done in healthy and sick horses using the chromogenic substrate Chromozym TH. Reference values for adult horses at 25 degrees C were 18-25 IU AT III per ml plasma and 84-118% AT III activity of normal horse plasma, respectively. Precision and accuracy were good (intra assay coefficient of variation less than 2%, accuracy 10%). Surgical operations on healthy horses led to a biphasic decrease in AT III activity touching the lower border of the reference values on the second postoperative day. Other reasons for acquired AT III deficiencies included disseminated intravascular coagulation (DIC), liver disease and glomerulonephritis. Using follow-up studies, differences in the dynamics of acquired AT III deficiency and coagulation promoting factors were demonstrated. 12 of 35 horses with decreased AT III values suffered from phlebothrombosis of the jugular veins. It was presumed that acquired AT III deficiencies promote development and progression of phlebothrombosis/thrombophlebitis in horses.
使用发色底物Chromozym TH对健康马匹和患病马匹进行抗凝血酶III（AT III）测定。25摄氏度下成年马的参考值分别为每毫升血浆18 - 25 IU AT III以及正常马血浆AT III活性的84 - 118%。精密度和准确度良好（批内变异系数小于2%，准确度为10%）。对健康马匹进行手术导致AT III活性呈双相下降，在术后第二天降至参考值下限。获得性AT III缺乏的其他原因包括弥散性血管内凝血（DIC）、肝病和肾小球肾炎。通过随访研究，证明了获得性AT III缺乏和促凝血因子动态变化的差异。35匹AT III值降低的马匹中有12匹患有颈静脉血栓形成。据推测，获得性AT III缺乏会促进马匹静脉血栓形成/血栓性静脉炎的发生和发展。
