Holland M, Kelly A B, Snyder J R, Steffey E P, Willits N, McNeal D
Am J Vet Res. 1986 Apr;47(4):897-900.
A chromogenic peptide substrate assay was used to determine serially plasma antithrombin III (AT III) activity in 4 groups of horses. Group I consisted of healthy, mature horses in which AT III activity was determined twice daily for 7 consecutive days. Groups 2 and 3 contained healthy horses in which AT III activity was monitored for 7 days after controlled, but varying, conditions of general anesthesia and surgery (median celiotomy). Group 4 was made up of patients with a presurgical diagnosis of colonic torsion. In healthy awake horses (group I), there was no difference in AT III values over time. Postoperative AT III activity in the halothane-anesthetized horses (group 2) and in the sham-operated horses (group 3) was not significantly (P = 0.05) different from base-line values at any time. A significant decrease (P = 0.05) in AT III activity was observed on postoperative days 1 through 3 in the group of horses with large colon torsion, but returned to preoperative values by day 4 after surgery in the horses that survived. In those horses that did not survive, AT III activity remained below base-line values for the duration of observation. Seemingly, plasma AT III activity in horses was not significantly affected by halothane anesthesia or surgery. Serial evaluation of AT III activity may be useful for predicting survival in horses with large colon torsion.
采用发色肽底物分析法连续测定4组马的血浆抗凝血酶III（AT III）活性。第一组由健康成年马组成，连续7天每天测定两次AT III活性。第二组和第三组包含健康马，在可控但不同的全身麻醉和手术（中位剖腹术）条件下监测AT III活性7天。第四组由术前诊断为结肠扭转的病马组成。在健康清醒马（第一组）中，AT III值随时间无差异。氟烷麻醉马（第二组）和假手术马（第三组）术后任何时间的AT III活性与基线值相比均无显著差异（P = 0.05）。在患有大结肠扭转的马组中，术后第1至3天观察到AT III活性显著降低（P = 0.05），但存活马在术后第4天恢复到术前值。在那些未存活的马中，AT III活性在观察期间一直低于基线值。似乎，氟烷麻醉或手术对马的血浆AT III活性没有显著影响。连续评估AT III活性可能有助于预测大结肠扭转马的存活情况。
