Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Ave, St. Paul, MN 55108, USA; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Unit Porcine Health Management, Ghent University, Salisburylaan, 133 B-9820 Merelbeke, Belgium.
Vet J. 2022 Oct;288:105877. doi: 10.1016/j.tvjl.2022.105877. Epub 2022 Jul 25.
Mycoplasma hyopneumoniae remains one of the most problematic bacterial pathogens for pig production. Despite an abundance of observational and laboratory testing capabilities for this organism, diagnostic interpretation of test results can be challenging and ambiguous. This is partly explained by the chronic nature of M. hyopneumoniae infection and its tropism for lower respiratory tract epithelium, which affects diagnostic sensitivities associated with sampling location and stage of infection. A thorough knowledge of the available tools for routine M. hyopneumoniae diagnostic testing, together with a detailed understanding of infection dynamics, are essential for optimizing sampling strategies and providing confidence in the diagnostic process. This study reviewed known information on sampling and diagnostic tools for M. hyopneumoniae and summarized literature reports of the dynamics of key infection outcomes, including clinical signs, lung lesions, pathogen detection, and humoral immune responses. The information gathethered in this manuscript can facilitate better understanding of the performance of different diagnostic approaches at various stages of infection with Mycoplasma hyopneumoniae.
猪肺炎支原体仍然是猪生产中最具问题的细菌性病原体之一。尽管有大量针对该病原体的观察和实验室检测能力，但对检测结果的诊断解释可能具有挑战性和模糊性。这部分是由于猪肺炎支原体感染的慢性性质及其对下呼吸道上皮的趋向性，这影响了与采样位置和感染阶段相关的诊断敏感性。全面了解用于常规猪肺炎支原体诊断检测的可用工具，并详细了解感染动态，对于优化采样策略和对诊断过程充满信心至关重要。本研究综述了猪肺炎支原体采样和诊断工具的已知信息，并总结了关键感染结果（包括临床症状、肺部病变、病原体检测和体液免疫反应）的文献报告。本研究汇集的信息有助于更好地了解在猪肺炎支原体感染的不同阶段不同诊断方法的性能。
