雄性大鼠中二溴氯丙烷的性腺毒性及动力学

Gonadotoxicity and kinetics of dibromochloropropane in male rats.

作者信息

Shemi D, Sod-Moriah U A, Kaplanski J, Potashnik G, Bitan A P, Buchman O

出版信息

Toxicol Lett. 1987 May;36(3):209-12. doi: 10.1016/0378-4274(87)90187-1.

Abstract

Adult male rats were injected with [3H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 X 10(6) dpm. Blood from the tail and 24-h urine samples were collected up to 2 days post-injection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that there is no preference in labelling of the testes compared with other organs, and the kidney and liver may have an important role in the elimination of DBCP.

摘要

成年雄性大鼠被注射溶解于含约10×10⁶ 每分钟衰变数（dpm）二甲基亚砜中的[³H]二溴氯丙烷。注射后长达2天收集尾血和24小时尿液样本。在注射后7小时和7天，进一步从肾脏、肝脏、脾脏、肾上腺、附睾、精囊和睾丸采集组织样本。结果表明，与其他器官相比，睾丸在标记方面没有偏好，并且肾脏和肝脏在二溴氯丙烷的消除中可能起重要作用。