Malik J K, Srivastava A K
Toxicol Lett. 1987 May;36(3):221-6. doi: 10.1016/0378-4274(87)90189-5.
The effect of manganese pretreatment on acute toxicity of fenitrothion (FTH) was investigated in male rats by assessing the degree of enzymatic alterations. Oral administration of FTH (260 mg/kg) markedly inactivated cholinesterase (ChE) and carboxylesterase and elevated the activities of acid phosphatase, alanine aminotransferase and aspartate aminotransferase in different tissues 3 h after dosing. Pretreatment of rats with manganese (10 mg/kg, i.p.) 3 days prior to FTH application (260 mg/kg, p.o.) significantly enhanced these enzymatic changes. The results indicate that inhibition of esterases and elevation in other enzymes induced by manganese are likely to contribute to the increased enzymatic alterations observed following combined treatment.
通过评估酶变化程度，研究了锰预处理对雄性大鼠体内杀螟硫磷（FTH）急性毒性的影响。口服给予FTH（260mg/kg）能显著使胆碱酯酶（ChE）和羧酸酯酶失活，并在给药3小时后提高不同组织中酸性磷酸酶、丙氨酸转氨酶和天冬氨酸转氨酶的活性。在给予FTH（260mg/kg，口服）前3天，用锰（10mg/kg，腹腔注射）对大鼠进行预处理，可显著增强这些酶变化。结果表明，锰诱导的酯酶抑制和其他酶活性升高可能导致联合处理后观察到的酶变化增加。
