Bamford J, Sandercock P, Jones L, Warlow C
Stroke. 1987 May-Jun;18(3):545-51. doi: 10.1161/01.str.18.3.545.
In a consecutive series of 515 first-ever strokes in a community-based study of stroke that combined prompt clinical assessment by a study neurologist with a high rate of confirmed pathologic diagnosis, 108 cases (21%) had a lacunar syndrome. A computed tomography (CT) scan was performed in 104 (96%) of these cases. Only 3 cases had primary intracerebral hemorrhage, and another 3 had "inappropriate" areas of infarcts were seen in 34 of the remaining 98 (35%) CT scans. The crude annual incidence of lacunar infarction was 0.33/1,000. There was no excess risk among men. The case fatality rates were 1% at 1 month and 9.8% at 1 year. The rate of recurrent strokes was 11.8% in the first year. Among patients surviving 1 year, 66% were capable of independent existence.
在一项基于社区的卒中研究中，对连续515例首次发生卒中的患者进行了研究，该研究将研究神经科医生的快速临床评估与高确诊病理诊断率相结合，其中108例（21%）患有腔隙综合征。这些病例中有104例（96%）进行了计算机断层扫描（CT）。只有3例为原发性脑出血，另外3例在其余98例（35%）CT扫描中有“不适当”的梗死区域。腔隙性梗死的粗年发病率为0.33/1000。男性中没有额外风险。1个月时的病死率为1%，1年时为9.8%。第一年的卒中复发率为11.8%。在存活1年的患者中，66%能够独立生活。
