Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
School of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
AAPS PharmSciTech. 2022 Jul 28;23(6):208. doi: 10.1208/s12249-022-02325-6.
High oil ratio fat emulsion injections are prone to poor emulsification, rapid creaming, and other quality problems; therefore, the selection of emulsifiers with high emulsifying ability is crucial for the production of fat emulsions. The existing methods used to evaluate the emulsifying ability of emulsifier are to evaluate the emulsifying ability from the emulsifier itself. In the study, Langmuir monolayer selected the most miscible phospholipid with oil phase from the alternative three phospholipids by studying the molecular interaction between oil phase and phospholipid at the air/water interface. The miscibility and thermodynamic stability analyses of the different oil phase/phospholipid mixed monolayers were performed, and the data from [Formula: see text] and [Formula: see text] concluded that all three oil phases had the strongest molecular interaction with E80 and the best miscibility. The emulsions were then prepared and analyzed by the results of particle size, ζ-potential, and stability of the emulsions, where the surface free energy in the stability test echoed the results reflected by the [Formula: see text] values in the thermodynamic stability test. These results indicate that Langmuir monolayers can be used to study the interaction between oil phase and emulsifier, thus providing new ideas for evaluating the emulsifying ability of phospholipids.
高油比脂肪乳注射液容易乳化不良、迅速分层等质量问题；因此，选择具有高乳化能力的乳化剂对于脂肪乳的生产至关重要。现有的评价乳化剂乳化能力的方法都是从乳化剂本身来评价其乳化能力。本研究通过研究油相与磷脂在气/水界面的分子相互作用，从三种替代磷脂中选择了与油相最混溶的磷脂，从而选择出最适用于生产脂肪乳的乳化剂。对不同油相/磷脂混合单层的混溶性和热力学稳定性进行了分析，通过[Formula: see text]和[Formula: see text]的数据得出，所有三种油相与 E80 具有最强的分子相互作用和最佳的混溶性。然后根据粒径、ζ-电位和乳液稳定性的结果制备和分析乳液，其中稳定性测试中的表面自由能与热力学稳定性测试中[Formula: see text]值反映的结果相呼应。这些结果表明，Langmuir 单层可以用于研究油相与乳化剂之间的相互作用，从而为评价磷脂的乳化能力提供了新的思路。
