Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, NO.150 Haping ST, Nangang District, Harbin, Heilongjiang, People's Republic of China, 150081.
Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin Medical University, NO.150 Haping ST, Nangang District, Harbin, Heilongjiang, People's Republic of China, 150081.
BMC Cancer. 2022 Jul 28;22(1):823. doi: 10.1186/s12885-022-09834-4.
As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of innate immune cells. Patients with different microsatellite statuses have distinct immune profiles. This study aimed to investigate the association of plasma CLEC-2 levels with microsatellite status among colorectal cancer (CRC) patients.
A cross-sectional analysis of 430 CRC patients from Harbin Medical University Cancer Hospital was conducted. CLEC-2 levels were measured with fasting venous blood samples drawn from each participant before any treatment. The microsatellite status was evaluated with DNA obtained from fresh frozen tumor tissue samples. The other clinical data were collected and recorded based on the medical system records.
CLEC-2 levels were significantly higher among patients with high microsatellite instability phenotype than the stable microsatellite group, adjusting for other confounding variables.
The increased CLEC-2 is associated with the high microsatellite instability subtype of CRC.
作为一种跨膜蛋白，C 型凝集素样受体 2（CLEC-2）主要表达于血小板上，并在血小板活化后释放入血浆。活化的血小板参与固有免疫细胞的调节。具有不同微卫星状态的患者具有不同的免疫特征。本研究旨在探讨结直肠癌（CRC）患者血浆 CLEC-2 水平与微卫星状态之间的关系。
对来自哈尔滨医科大学附属肿瘤医院的 430 例 CRC 患者进行横断面分析。在进行任何治疗之前，通过采集每位参与者的空腹静脉血样来测量 CLEC-2 水平。使用从新鲜冷冻肿瘤组织样本中提取的 DNA 来评估微卫星状态。根据医疗系统记录收集和记录其他临床数据。
在调整其他混杂变量后，高微卫星不稳定性表型患者的 CLEC-2 水平明显高于稳定微卫星组。
升高的 CLEC-2 与 CRC 的高微卫星不稳定性亚型相关。
