Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Cancer Biomark. 2021;31(4):351-359. doi: 10.3233/CBM-203250.
Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis and a more effective immune response than patients with microsatellite stable (MSS) CRC. Moreover, activated platelets play a crucial role in modulating innate immune cells. Mean platelet volume (MPV) is an indicator of platelet activation. This study is to examine the association between MPV and MSI status in CRC.
We collected the clinical and pathological variables of 424 CRC patients diagnosed at the Harbin Medical University Cancer Hospital from January 2018 to December 2018. Associations between MPV levels and MSI status were examined. Propensity score matching (PSM) was performed to reduce the possibility of selection bias.
424 CRC patients were divided into low-MPV group and high-MPV group according to the optimal cut-off value of MPV. 131 high-MPV patients were matched to low-MPV counterparts in a 1:1 ratio by propensity score matching. As MPV levels increased, the percentage of patients with MSI-H reduced. Furthermore, compared with MSS group, the MSI-H group had a significantly lower MPV levels (p= 0.003 after matching). In addition, logistic regression analysis identified reduced MPV as an independent risk factor for MSI-H in CRC patients after controlling for other potential parameters.
Lower MPV is associated with MSI-H subtype of CRC. Further study on MPV in MSI-H CRC is warranted.
微卫星不稳定高（MSI-H）结直肠癌（CRC）患者的预后通常比微卫星稳定（MSS）CRC 患者更好，并且对免疫治疗的反应更有效。此外，激活的血小板在调节先天免疫细胞中起着至关重要的作用。平均血小板体积（MPV）是血小板激活的指标。本研究旨在探讨 CRC 中 MPV 与 MSI 状态之间的关系。
我们收集了 2018 年 1 月至 2018 年 12 月在哈尔滨医科大学附属肿瘤医院诊断的 424 例 CRC 患者的临床和病理变量。检查了 MPV 水平与 MSI 状态之间的关联。进行倾向评分匹配（PSM）以减少选择偏差的可能性。
根据 MPV 的最佳截断值，将 424 例 CRC 患者分为低-MPV 组和高-MPV 组。通过倾向评分匹配，以 1:1 的比例将 131 例高-MPV 患者与低-MPV 患者相匹配。随着 MPV 水平的升高，MSI-H 患者的比例降低。此外，与 MSS 组相比，MSI-H 组的 MPV 水平明显降低（匹配后 p=0.003）。此外，逻辑回归分析确定在控制其他潜在参数后，MPV 降低是 CRC 患者 MSI-H 的独立危险因素。
较低的 MPV 与 CRC 的 MSI-H 亚型相关。需要进一步研究 MSI-H CRC 中的 MPV。
